Title | The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Bosse, JB, Enquist, LW |
Journal | Nucleus |
Volume | 7 |
Issue | 1 |
Pagination | 13-9 |
Date Published | 2016 |
ISSN | 1949-1042 |
Keywords | Animals, Capsid, Cytoplasm, Herpesviridae, Humans, Nuclear Envelope |
Abstract | <p>Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125 nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.</p> |
DOI | 10.1080/19491034.2016.1149665 |
Alternate Journal | Nucleus |
PubMed ID | 26889771 |
PubMed Central ID | PMC4916875 |
Grant List | R01 NS033506 / NS / NINDS NIH HHS / United States R01 NS060699 / NS / NINDS NIH HHS / United States NS033506 / NS / NINDS NIH HHS / United States NS060699 / NS / NINDS NIH HHS / United States |