Definitions and guidelines for research on antibiotic persistence.

TitleDefinitions and guidelines for research on antibiotic persistence.
Publication TypeJournal Article
Year of Publication2019
AuthorsBalaban, NQ, Helaine, S, Lewis, K, Ackermann, M, Aldridge, B, Andersson, DI, Brynildsen, MP, Bumann, D, Camilli, A, Collins, JJ, Dehio, C, Fortune, S, Ghigo, J-M, Hardt, W-D, Harms, A, Heinemann, M, Hung, DT, Jenal, U, Levin, BR, Michiels, J, Storz, G, Tan, M-W, Tenson, T, Van Melderen, L, Zinkernagel, A
JournalNat Rev Microbiol
Volume17
Issue7
Pagination441-448
Date Published2019 07
ISSN1740-1534
KeywordsAnti-Bacterial Agents, Bacteria, Biomedical Research, Drug Tolerance, Guidelines as Topic, Terminology as Topic
Abstract

<p>Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.</p>

DOI10.1038/s41579-019-0196-3
Alternate JournalNat Rev Microbiol
PubMed ID30980069
PubMed Central IDPMC7136161
Grant ListMR/P028225/1 / MRC_ / Medical Research Council / United Kingdom
R01 AI055058 / AI / NIAID NIH HHS / United States
R01 GM091875 / GM / NIGMS NIH HHS / United States
R37 AI055058 / AI / NIAID NIH HHS / United States