Decoding type I and III interferon signalling during viral infection.

TitleDecoding type I and III interferon signalling during viral infection.
Publication TypeJournal Article
Year of Publication2019
AuthorsMesev, EV, LeDesma, RA, Ploss, A
JournalNat Microbiol
Volume4
Issue6
Pagination914-924
Date Published2019 06
ISSN2058-5276
KeywordsAnimals, Antiviral Agents, Gene Expression Regulation, Host-Pathogen Interactions, Humans, Immune Evasion, Immunity, Innate, Interferon Type I, Interferons, Signal Transduction, Tropism, Virus Diseases, Viruses
Abstract

<p>Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.</p>

DOI10.1038/s41564-019-0421-x
Alternate JournalNat Microbiol
PubMed ID30936491
PubMed Central IDPMC6554024
Grant ListR01 AI107301 / AI / NIAID NIH HHS / United States
R01 AI138797 / AI / NIAID NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States