Decoding type I and III interferon signalling during viral infection.

TitleDecoding type I and III interferon signalling during viral infection.
Publication TypeJournal Article
Year of Publication2019
AuthorsMesev, EV, LeDesma, RA, Ploss, A
JournalNat Microbiol
Date Published2019 Apr 01
ISSN2058-5276
Abstract

Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.

DOI10.1038/s41564-019-0421-x
Alternate JournalNat Microbiol
PubMed ID30936491