Title | Decoding type I and III interferon signalling during viral infection. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Mesev, EV, LeDesma, RA, Ploss, A |
Journal | Nat Microbiol |
Volume | 4 |
Issue | 6 |
Pagination | 914-924 |
Date Published | 2019 06 |
ISSN | 2058-5276 |
Keywords | Animals, Antiviral Agents, Gene Expression Regulation, Host-Pathogen Interactions, Humans, Immune Evasion, Immunity, Innate, Interferon Type I, Interferons, Signal Transduction, Tropism, Virus Diseases, Viruses |
Abstract | <p>Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.</p> |
DOI | 10.1038/s41564-019-0421-x |
Alternate Journal | Nat Microbiol |
PubMed ID | 30936491 |
PubMed Central ID | PMC6554024 |
Grant List | R01 AI107301 / AI / NIAID NIH HHS / United States R01 AI138797 / AI / NIAID NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |