Decoding the Role of Temperature in RNA Virus Infections.

TitleDecoding the Role of Temperature in RNA Virus Infections.
Publication TypeJournal Article
Year of Publication2022
AuthorsBisht, K, Velthuis, AJWTe
JournalmBio
Paginatione0202122
Date Published2022/08/18
ISSN2150-7511
Abstract

RNA viruses include respiratory viruses, such as coronaviruses and influenza viruses, as well as vector-borne viruses, like dengue and West Nile virus. RNA viruses like these encounter various environments when they copy themselves and spread from cell to cell or host to host. differences, such as geographical location and humidity, affect their stability and transmission, while differences, such as pH and host gene expression, impact viral receptor binding, viral replication, and the host immune response against the viral infection. A critical factor affecting RNA viruses both and , and defining the outcome of viral infections and the direction of viral evolution, is temperature. In this minireview, we discuss the impact of temperature on viral replication, stability, transmission, and adaptation, as well as the host innate immune response. Improving our understanding of how RNA viruses function, survive, and spread at different temperatures will improve our models of viral replication and transmission risk analyses.

DOI10.1128/mbio.02021-22
Alternate JournalmBio
PubMed ID35980031
Grant List206579/Z/17/Z / WT_ / Wellcome Trust / United Kingdom