Decoding locomotion from population neural activity in moving .

TitleDecoding locomotion from population neural activity in moving .
Publication TypeJournal Article
Year of Publication2021
AuthorsHallinen, KM, Dempsey, R, Scholz, M, Yu, X, Linder, A, Randi, F, Sharma, AK, Shaevitz, JW, Leifer, AM
JournalElife
Volume10
Date Published2021 07 29
ISSN2050-084X
KeywordsAnimals, Brain, Caenorhabditis elegans, Motor Activity, Neurons
Abstract

<p>We investigated the neural representation of locomotion in the nematode by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion than any single neuron. Relevant signals are distributed across neurons with diverse tunings to locomotion. Two largely distinct subpopulations are informative for decoding velocity and curvature, and different neurons' activities contribute features relevant for different aspects of a behavior or different instances of a behavioral motif. To validate our measurements, we labeled neurons AVAL and AVAR and found that their activity exhibited expected transients during backward locomotion. Finally, we compared population activity during movement and immobilization. Immobilization alters the correlation structure of neural activity and its dynamics. Some neurons positively correlated with AVA during movement become negatively correlated during immobilization and vice versa. This work provides needed experimental measurements that inform and constrain ongoing efforts to understand population dynamics underlying locomotion in .</p>

DOI10.7554/eLife.66135
Alternate JournalElife
PubMed ID34323218
PubMed Central IDPMC8439659
Grant ListP40 OD010440 / OD / NIH HHS / United States
T32 MH065214 / MH / NIMH NIH HHS / United States