Cutting through the complexity of cell collectives.

TitleCutting through the complexity of cell collectives.
Publication TypeJournal Article
Year of Publication2013
AuthorsNadell, CD, Bucci, V, Drescher, K, Levin, SA, Bassler, BL, Xavier, JB
JournalProc Biol Sci
Date Published2013 Mar 22
KeywordsBacteria, Bacterial Physiological Phenomena, Biofilms, Biological Evolution, Models, Biological, Quorum Sensing, Selection, Genetic

<p>Via strength in numbers, groups of cells can influence their environments in ways that individual cells cannot. Large-scale structural patterns and collective functions underpinning virulence, tumour growth and bacterial biofilm formation are emergent properties of coupled physical and biological processes within cell groups. Owing to the abundance of factors influencing cell group behaviour, deriving general principles about them is a daunting challenge. We argue that combining mechanistic theory with theoretical ecology and evolution provides a key strategy for clarifying how cell groups form, how they change in composition over time, and how they interact with their environments. Here, we review concepts that are critical for dissecting the complexity of cell collectives, including dimensionless parameter groups, individual-based modelling and evolutionary theory. We then use this hybrid modelling approach to provide an example analysis of the evolution of cooperative enzyme secretion in bacterial biofilms.</p>

Alternate JournalProc Biol Sci
PubMed ID23363630
PubMed Central IDPMC3574390
Grant ListDP2OD008440 / OD / NIH HHS / United States
R01 GM065859 / GM / NIGMS NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States
P30 CA008748 / CA / NCI NIH HHS / United States
U54 CA148967 / CA / NCI NIH HHS / United States
DP2 OD008440 / OD / NIH HHS / United States
1-U54-CA148967-01 / CA / NCI NIH HHS / United States
5R01GM065859 / GM / NIGMS NIH HHS / United States