Cracking outer membrane biogenesis.

TitleCracking outer membrane biogenesis.
Publication TypeJournal Article
Year of Publication2023
AuthorsGuest, RL, Silhavy, TJ
JournalBiochim Biophys Acta Mol Cell Res
Volume1870
Issue2
Pagination119405
Date Published2023 Feb
ISSN1879-2596
KeywordsAnti-Bacterial Agents, Bacterial Outer Membrane Proteins
Abstract

<p>The outer membrane is a distinguishing feature of the Gram-negative envelope. It lies on the external face of the peptidoglycan sacculus and forms a robust permeability barrier that protects extracytoplasmic structures from environmental insults. Overcoming the barrier imposed by the outer membrane presents a significant hurdle towards developing novel antibiotics that are effective against Gram-negative bacteria. As the outer membrane is an essential component of the cell, proteins involved in its biogenesis are themselves promising antibiotic targets. Here, we summarize key findings that have built our understanding of the outer membrane. Foundational studies describing the discovery and composition of the outer membrane as well as the pathways involved in its construction are discussed.</p>

DOI10.1016/j.bbamcr.2022.119405
Alternate JournalBiochim Biophys Acta Mol Cell Res
PubMed ID36455781
PubMed Central IDPMC9878550