Cortical and Subcortical Contributions to Short-Term Memory for Orienting Movements.

TitleCortical and Subcortical Contributions to Short-Term Memory for Orienting Movements.
Publication TypeJournal Article
Year of Publication2015
AuthorsKopec, CD, Erlich, JC, Brunton, BW, Deisseroth, K, Brody, CD
Date Published2015 Oct 21
KeywordsAcoustic Stimulation, Animals, Cerebral Cortex, Male, Memory, Short-Term, Movement, Orientation, Rats, Rats, Long-Evans, Superior Colliculi

<p>Neural activity in frontal cortical areas has been causally linked to short-term memory (STM), but whether this activity is necessary for forming, maintaining, or reading out STM remains unclear. In rats performing a memory-guided orienting task, the frontal orienting fields in cortex (FOF) are considered critical for STM maintenance, and during each trial display a monotonically increasing neural encoding for STM. Here, we transiently inactivated either the FOF or the superior colliculus and found that the resulting impairments in memory-guided orienting performance followed a monotonically decreasing time course, surprisingly opposite to the neural encoding. A dynamical attractor model in which STM relies equally on cortical and subcortical regions reconciled the encoding and inactivation data. We confirmed key predictions of the model, including a time-dependent relationship between trial difficulty and perturbability, and substantial, supralinear, impairment following simultaneous inactivation of the FOF and superior colliculus during memory maintenance.</p>

Alternate JournalNeuron
PubMed ID26439529
PubMed Central IDPMC5521275
Grant ListT32 MH065214 / MH / NIMH NIH HHS / United States