Jiang X, Yan N, Deng D, Yan C. Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect. IUBMB Life. 2022;74(12):1180–1199. PMID: 36082803

Yao X, Gao S, Yan N. Structural basis for pore blockade of human voltage-gated calcium channel Ca1.3 by motion sickness drug cinnarizine. Cell Res. 2022;32(10):946–948. PMCID: PMC9525318

Wang N, Zhang S, Yuan Y, Xu H, Defossa E, Matter H, Besenius M, Derdau V, Dreyer M, Halland N, He K, Petry S, Podeschwa M, Tennagels N, Jiang X, Yan N. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nat Commun. 2022;13(1):2632. PMCID: PMC9098912

Yuan Y, Kong F, Xu H, Zhu A, Yan N, Yan C. Cryo-EM structure of human glucose transporter GLUT4. Nat Commun. 2022;13(1):2671. PMCID: PMC9106701

Wu X, Yan R, Cao P, Qian H, Yan N. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022;47(4):289–300. PMID: 35012873

Gao S, Yao X, Yan N. Structure of human Ca2.2 channel blocked by the painkiller ziconotide. Nature. 2021;596(7870):143–147. PMCID: PMC8529174

Shen H, Yan N, Pan X. Structural determination of human Na1.4 and Na1.7 using single particle cryo-electron microscopy. Methods Enzymol. 2021;653:103–120. PMID: 34099168

Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021;35(13):109299. PMID: 34192549

Liu C, Zhang A, Yan N, Song C. Atomistic Details of Charge/Space Competition in the Ca Selectivity of Ryanodine Receptors. J Phys Chem Lett. 2021;12(17):4286–4291. PMID: 33909426

Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, Pan X, Yan N. Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na 1.5 by the Antiarrhythmic Drug Quinidine*. Angew Chem Int Ed Engl. 2021;60(20):11474–11480. PMID: 33684260

Li Z, Jin X, Wu T, Zhao X, Wang W, Lei J, Pan X, Yan N. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021;118(11). PMCID: PMC7980460

Pan X, Li Z, Jin X, Zhao Y, Huang G, Huang X, Shen Z, Cao Y, Dong M, Lei J, Yan N. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021;118(11). PMCID: PMC7980448

Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021;118(3). PMCID: PMC7826358

Yan R, Cao P, Song W, Qian H, Du X, Coates H, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown A, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021;371(6533). PMID: 33446483

Gong D, Yan N, Ledford H. Structural Basis for the Modulation of Ryanodine Receptors. Trends Biochem Sci. 2021;46(6):489–501. PMID: 33353849

Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M. Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020;11(1):5686. PMCID: PMC7655804

Gao S, Yan N. Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca 1.1 by Dihydropyridine Compounds*. Angew Chem Int Ed Engl. 2021;60(6):3131–3137. PMCID: PMC7898392

Thomas C, Aller S, Beis K, Carpenter E, Chang G, Chen L, Dassa E, Dean M, Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland B, Huang Y, Kahne D, Kato H, Koronakis V, Koth C, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett H, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng S-L, Slotboom D, Tajkhorshid E, Tieleman P, Ueda K, Váradi A, Wen P-C, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. Structural and functional diversity calls for a new classification of ABC transporters. FEBS Lett. 2020;594(23):3767–3775. PMCID: PMC8386196

Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, Pu D, Zhao N, Tang Q, Hirata K, Yang X, Jiao Y, Sakata-Kato T, Wu J-W, Yan C, Kato N, Yin H, Yan N. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020;183(1):258–268.e12. PMID: 32860739

Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020;117(31):18497–18503. PMCID: PMC7414195

Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020;182(1):98–111.e18. PMID: 32544384

Gao S, Valinsky W, On N, Houlihan P, Qu Q, Liu L, Pan X, Clapham D, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020;117(25):14187–14193. PMCID: PMC7322032

Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad B, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020;581(7808):329–332. PMCID: PMC7255049

Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong C, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020;581(7808):333–338. PMCID: 5093084

Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, Lei J, Yan N. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019;177(6):1495–1506.e12. PMID: 31150622

Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A. 2019;116(51):25575–25582. PMCID: PMC6926060

Han Y, Fan X, Wang H, Zhao F, Tully C, Kong J, Yao N, Yan N. High-yield monolayer graphene grids for near-atomic resolution cryoelectron microscopy. Proc Natl Acad Sci U S A. 2020;117(2):1009–1014. PMCID: PMC6969529

Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019;576(7787):492–497. PMCID: 18083096

Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen S, Yan N. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019;572(7769):347–351. PMID: 31278385

Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019;10(1):2320. PMCID: PMC6534611

Brown A, Chua N, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019;10(1):888. PMCID: PMC6384927

Jiang X, Wu J, Ke M, Zhang S, Yuan Y, Lin J, Yan N. Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs. Cell Discov. 2019;5:14. PMCID: PMC6399220

Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019;363(6433):1303–1308. PMID: 30765606

Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, Liu L, Lei J, Yan N. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019;363(6433):1309–1313. PMID: 30765605

Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018;47(2):248–256.e4. PMID: 30293840

Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018;362(6412). PMID: 30190309

Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith J, K Y Chin Y, Lei J, Zhou Q, King G, Yan N. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018;362(6412). PMID: 30049784

Zhang J, Mao W, Ren Y, Sun R-N, Yan N, Gong H. Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaPaS. Protein Cell. 2018;9(6):580–585. PMCID: PMC5966359

Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018;361(6402). PMID: 29954986

Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009;16(12):1230–6. PMID: 19893533

Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N. Structure of the Na1.4-β1 Complex from Electric Eel. Cell. 2017;170(3):470–482.e11. PMID: 28735751

Yan N. A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters. J Mol Biol. 2017;429(17):2710–2725. PMID: 28756087

Deng D, Yan N. Crystallization and Structural Determination of the Human Glucose Transporters GLUT1 and GLUT3. Methods Mol Biol. 2018;1713:15–29. PMID: 29218514

Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu Y-N, Wang P, Yan N, Shi Y. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature. 2009;462(7272):467–72. PMID: 19940917

Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010;141(3):446–57. PMID: 20434985

Hao Q, Yin P, Yan C, Yuan X, Li W, Zhang Z, Liu L, Wang J, Yan N. Functional mechanism of the abscisic acid agonist pyrabactin. J Biol Chem. 2010;285(37):28946–52. PMCID: PMC2937921

Yuan X, Yin P, Hao Q, Yan C, Wang J, Yan N. Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2. J Biol Chem. 2010;285(37):28953–8. PMCID: PMC2937922

Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N. Structure of a fucose transporter in an outward-open conformation. Nature. 2010;467(7316):734–8. PMID: 20877283

Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, Deng D, Dang S, Zhang X, Wang J, Yan N. Structure and mechanism of the uracil transporter UraA. Nature. 2011;472(7342):243–6. PMID: 21423164

Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu J, Wang J, Yan F, Yan N. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Mol Cell. 2011;42(5):662–72. PMID: 21658606