1.Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408 Reference Link
1.Han E, Lee S, Hoshino S, Seyedsayamdost M. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem Biol. 2022;17(11):3121–3130. PMID: 36228140 Reference Link
1.Clark K, Seyedsayamdost M. Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine-Tryptophan Crosslink. J Am Chem Soc. 2022;144(39):17876–17888. PMID: 36128669 Reference Link
1.Kayrouz C, Huang J, Hauser N, Seyedsayamdost M. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature. 2022;610(7930):199–204. PMCID: 2881734 Reference Link
1.Clark K, Bushin L, Seyedsayamdost M. RaS-RiPPs in Streptococci and the Human Microbiome. ACS Bio Med Chem Au. 2022;2(4):328–339. PMCID: PMC9389541 Reference Link
1.Li Y, Lee S, Han E, Seyedsayamdost M. Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew Chem Int Ed Engl. 2022;61(39):e202208573. PMCID: PMC9489664 Reference Link
1.Bushin L, Covington B, Clark K, Caruso A, Seyedsayamdost M. Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs. Nat Chem Biol. 2022;18(10):1135–1143. PMCID: 6686864 Reference Link
1.Covington B, Seyedsayamdost M. Vitamin B3 Triggers Biosynthesis of Secondary Metabolite Dormancy Signals in . J Am Chem Soc. 2022;144(33):14997–15001. PMID: 35969232 Reference Link
1.Zhang Y, Gallant Étienne, Park J-D, Seyedsayamdost M. The Small-Molecule Language of Dynamic Microbial Interactions. Annu Rev Microbiol. 2022;76:641–660. PMID: 35679616 Reference Link
1.Lee S, Seyedsayamdost M. Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers. Angew Chem Int Ed Engl. 2022;61(29):e202204519. PMCID: PMC9276648 Reference Link
1.Horwitz S, Blue T, Ambarian J, Hoshino S, Seyedsayamdost M, Davis K. Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines. RSC Chem Biol. 2022;3(4):420–425. PMCID: PMC8984913 Reference Link
1.Covington B, Seyedsayamdost M. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022;665:305–323. PMCID: PMC9078877 Reference Link
1.Covington B, Seyedsayamdost M. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021;16(12):2825–2833. PMCID: PMC9090437 Reference Link
1.Park J-D, Li Y, Moon K, Han E, Lee S, Seyedsayamdost M. Structural Elucidation of Cryptic Algaecides in Marine Algal-Bacterial Symbioses by NMR Spectroscopy and MicroED. Angew Chem Int Ed Engl. 2022;61(4):e202114022. PMCID: PMC9056321 Reference Link
1.Rued B, Covington B, Bushin L, Szewczyk G, Laczkovich I, Seyedsayamdost M, Federle M. Erratum for Rued et al., "Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound". mBio. 2021;12(5):e0256021. PMCID: PMC8546554 Reference Link
1.Forneris C, Nguy A, Seyedsayamdost M. Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. ACS Catal. 2020;10(16):9287–9298. PMCID: PMC8378672 Reference Link
1.Caruso A, Seyedsayamdost M. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021;86(16):11284–11289. PMID: 34351169 Reference Link
1.Wang R, Gallant Étienne, Wilson M, Wu Y, Li A, Gitai Z, Seyedsayamdost M. Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens. Cell Chem Biol. 2022;29(4):670–679.e5. PMCID: PMC8866538 Reference Link
1.Li A, Okada B, Rosen P, Seyedsayamdost M. Piperacillin triggers virulence factor biosynthesis via the oxidative stress response in . Proc Natl Acad Sci U S A. 2021;118(26). PMCID: PMC8256049 Reference Link
1.Yoshimura A, Covington B, Gallant Étienne, Zhang C, Li A, Seyedsayamdost M. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020;15(10):2766–2774. PMCID: PMC7572862 Reference Link
1.Balo A, Caruso A, Tao L, Tantillo D, Seyedsayamdost M, Britt D. Trapping a cross-linked lysine-tryptophan radical in the catalytic cycle of the radical SAM enzyme SuiB. Proc Natl Acad Sci U S A. 2021;118(21). PMCID: PMC8166192 Reference Link
1.Bushin L, Covington B, Rued B, Federle M, Seyedsayamdost M. Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome. J Am Chem Soc. 2020;142(38):16265–16275. PMID: 32845143 Reference Link
1.Covington B, Xu F, Seyedsayamdost M. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu Rev Biochem. 2021;90:763–788. PMCID: PMC9148385 Reference Link
1.Rued B, Covington B, Bushin L, Szewczyk G, Laczkovich I, Seyedsayamdost M, Federle M. Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound. mBio. 2021;12(2). PMCID: PMC8092268 Reference Link
1.Chen Y-C, Seyedsayamdost M, Ringstad N. A microbial metabolite synergizes with endogenous serotonin to trigger reproductive behavior. Proc Natl Acad Sci U S A. 2020;117(48):30589–30598. PMCID: PMC7720207 Reference Link
1.Isley N, Endo Y, Wu Z-C, Covington B, Bushin L, Seyedsayamdost M, Boger D. Total Synthesis and Stereochemical Assignment of Streptide. J Am Chem Soc. 2019;141(43):17361–17369. PMCID: PMC6821584 Reference Link
1.Klaus J, Coulon P, Koirala P, Seyedsayamdost M, Déziel E, Chandler J. Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution. J Ind Microbiol Biotechnol. 2020;47(9-10):877–887. PMCID: PMC7746414 Reference Link
1.Vrla G, Esposito M, Zhang C, Kang Y, Seyedsayamdost M, Gitai Z. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020;16(9):e1008867. PMCID: PMC7515202 Reference Link
1.Zhang C, Seyedsayamdost M. Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening. Angew Chem Int Ed Engl. 2020;59(51):23005–23009. PMID: 32790054 Reference Link
1.Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328 Reference Link
1.Zhang C, Seyedsayamdost M. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020;15(4):890–894. PMID: 32191027 Reference Link
1.Seyedsayamdost M, Stallforth P. Special Issue in Honor of Professor Jon Clardy. J Nat Prod. 2020;83(3):565–568. PMID: 32216264 Reference Link
1.Li A, Mao D, Yoshimura A, Rosen P, Martin L, Gallant Étienne, Wühr M, Seyedsayamdost M. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020;11(1). PMCID: PMC7042699 Reference Link
1.Greenberg P, Chandler J, Seyedsayamdost M. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020;83(3):738–743. PMCID: PMC8118907 Reference Link
1.Mao D, Yoshimura A, Wang R, Seyedsayamdost M. Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis. Chembiochem. 2020;21(13):1826–1831. PMCID: PMC7493819 Reference Link
1.Park J-D, Moon K, Miller C, Rose J, Xu F, Ebmeier C, Jacobsen J, Mao D, Old W, DeShazer D, Seyedsayamdost M. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020;15(5):1195–1203. PMCID: PMC9106368 Reference Link
1.Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325 Reference Link
1.Caruso A, Martinie R, Bushin L, Seyedsayamdost M. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical -Adenosylmethionine Enzymes. J Am Chem Soc. 2019;141(42):16610–16614. PMID: 31596076 Reference Link
1.Ozturk S, Forneris C, Nguy A, Sorensen E, Seyedsayamdost M. Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues. J Org Chem. 2018;83(13):7309–7317. PMID: 29806454 Reference Link
1.Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011 Reference Link
1.Xu F, Wu Y, Zhang C, Davis K, Moon K, Bushin L, Seyedsayamdost M. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019;15(2):161–168. PMCID: PMC6339573 Reference Link
1.Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422 Reference Link
1.Stubbe J, Seyedsayamdost M. Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer. Biochemistry. 2019;58(6):435–437. PMID: 30586288 Reference Link
1.Moon K, Xu F, Zhang C, Seyedsayamdost M. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem Biol. 2019;14(4):767–774. PMCID: PMC6813803 Reference Link
1.Moon K, Xu F, Seyedsayamdost M. Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES. Angew Chem Int Ed Engl. 2019;58(18):5973–5977. PMCID: PMC6779416 Reference Link
1.Okada B, Li A, Seyedsayamdost M. Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa. Chembiochem. 2019;20(15):2005–2011. PMCID: PMC6814388 Reference Link
1.Forneris C, Ozturk S, Sorensen E, Seyedsayamdost M. Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB. Tetrahedron. 2018;74(26):3231–3237. PMCID: PMC6205514 Reference Link
1.McRose D, Seyedsayamdost M, Morel F. Multiple siderophores: bug or feature?. J Biol Inorg Chem. 2018;23(7):983–993. PMID: 30264174 Reference Link
1.Forneris C, Seyedsayamdost M. In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants. Angew Chem Int Ed Engl. 2018;57(27):8048–8052. PMID: 29697176 Reference Link
1.Gibson M, Seyedsayamdost M. Small Biomolecules for Big Applications. ACS Cent Sci. 2018;4(4):437–439. PMCID: PMC5920611 Reference Link