Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz J. The small intestine shields the liver from fructose-induced steatosis. Nat Metab. 2020;2(7):586–593. PMCID: PMC8020332

Rabinowitz J, Enerbäck S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2(7):566–571. PMCID: PMC7983055

Xu Y, Zhang Y, García-Cañaveras J, Guo L, Kan M, Yu S, Blair I, Rabinowitz J, Yang X. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020;369(6502):397–403. PMCID: PMC7939502

Guan D, Xiong Y, Trinh T, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz J, Lazar M. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020;369(6509):1388–1394. PMCID: PMC7849028

Ghergurovich J, Esposito M, Chen Z, Wang J, Bhatt V, Lan T, White E, Kang Y, Guo J, Rabinowitz J. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020;80(18):3820–3829. PMCID: PMC7501231

Gibney P, Chen A, Schieler A, Chen J, Xu Y, Hendrickson D, McIsaac S, Rabinowitz J, Botstein D. A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. PLoS One. 2020;15(5):e0233779. PMCID: PMC7259636

Martin J, Sheehan J, Bratton B, Moore G, Mateus A, Li S, Kim H, Rabinowitz J, Typas A, Savitski M, Wilson M, Gitai Z. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020;181(7):1518–1532.e14. PMCID: PMC7780349

García-Cañaveras J, Lancho O, Ducker G, Ghergurovich J, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz J. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35(2):377–388. PMCID: PMC7647950

Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271

Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller K, Schug Z, Snyder N, Gade T, Titchenell P, Rabinowitz J, Wellen K. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020;579(7800):586–591. PMCID: PMC7416516

Yang L, Canaveras J, Chen Z, Wang L, Liang L, Jang C, Mayr J, Zhang Z, Ghergurovich J, Zhan L, Joshi S, Hu Z, McReynolds M, Su X, White E, Morscher R, Rabinowitz J. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020;31(4):809–821.e6. PMCID: PMC7397714

Hermans D, Gautam S, García-Cañaveras J, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin J-X, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers L, Rabinowitz J, Gattinoni L, Leonard W. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020;117(11):6047–6055. PMCID: PMC7084161

Li A, Ducker G, Li Y, Seoane J, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves E, Rankin E, Curtis C, Massagué J, Rabinowitz J, Thompson C, Ye J. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Mol Cancer Res. 2020;18(4):599–611. PMCID: PMC7127984

Benson K, Hu W, Weller A, Bennett A, Chen E, Khetarpal S, Yoshino S, Bone W, Wang L, Rabinowitz J, Voight B, Soccio R. Natural human genetic variation determines basal and inducible expression of , an obesity-associated gene. Proc Natl Acad Sci U S A. 2019;116(46):23232–23242. PMCID: PMC6859347

Dinh H, Suthers P, Chan S, Shen Y, Xiao T, Deewan A, Jagtap S, Zhao H, Rao C, Rabinowitz J, Maranas C. A comprehensive genome-scale model for IFO0880 accounting for functional genomics and phenotypic data. Metab Eng Commun. 2019;9:e00101. PMCID: PMC6838544

Stine R, Sakers A, TeSlaa T, Kissig M, Stine Z, Kwon C, Cheng L, Lim H-W, Kaestner K, Rabinowitz J, Seale P. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. 2019;25(6):830–845.e8. PMCID: PMC6898778

Ron-Harel N, Ghergurovich J, Notarangelo G, LaFleur M, Tsubosaka Y, Sharpe A, Rabinowitz J, Haigis M. T Cell Activation Depends on Extracellular Alanine. Cell Rep. 2019;28(12):3011–3021.e4. PMCID: PMC6934407

Park J, Tanner L, Wei M, Khana D, Jacobson T, Zhang Z, Rubin S, Li S, Higgins M, Stevenson D, Amador-Noguez D, Rabinowitz J. Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nat Chem Biol. 2019;15(10):1001–1008. PMID: 31548693

Lanaspa M, Andres-Hernando A, Orlicky D, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe M, Rabinowitz J, Johnson R, Tolan D. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018;128(6):2226–2238. PMCID: PMC5983342

Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O’Connor C, Dzinic S, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz J, Li J, Hou Z, Dann C, Gangjee A, Matherly L. Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy. Mol Cancer Ther. 2019;18(10):1787–1799. PMCID: PMC6774887

Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, Lim H-W, O’Connor S, Doan M, Cohen P, Baur J, King T, Veech R, Won K-J, Rabinowitz J, Snyder N, Gupta R, Seale P. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;30(1):174–189.e5. PMCID: PMC6836679

García-Cañaveras J, Chen L, Rabinowitz J. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019;79(13):3155–3162. PMCID: PMC6606343

Schober A, Mathis A, Ingle C, Park J, Chen L, Rabinowitz J, Junier I, Rivoire O, Reynolds K. A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism. Cell Rep. 2019;27(11):3359–3370.e7. PMCID: PMC6625508

Song Y, Park J, Tanner L, Nagano Y, Rabinowitz J, Shvartsman S. Energy budget of Drosophila embryogenesis. Curr Biol. 2019;29(12):R566-R567. PMCID: PMC9665180

Jang C, Hui S, Zeng X, Cowan A, Wang L, Chen L, Morscher R, Reyes J, Frezza C, Hwang H, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido G, Gorman J, Gorman R, Rabinowitz J. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2019;30(3):594–606.e3. PMCID: PMC6726553

Liu Q, Johnson E, Lam R, Wang Q, Ye H, Wilson E, Minhas P, Liu L, Swarovski M, Tran S, Wang J, Mehta S, Yang X, Rabinowitz J, Yang S, Shamloo M, Mueller C, James M, Andreasson K. Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Immunol. 2019;20(8):1023–1034. PMCID: PMC6778967

Su X, Lu W, Rabinowitz J. Metabolite Spectral Accuracy on Orbitraps. Anal Chem. 2017;89(11):5940–5948. PMCID: PMC5748891

Chen L, Zhang Z, Hoshino A, Zheng H, Morley M, Arany Z, Rabinowitz J. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019;1:404–415. PMCID: PMC6489125

Minhas P, Liu L, Moon P, Joshi A, Dove C, Mhatre S, Contrepois K, Wang Q, Lee B, Coronado M, Bernstein D, Snyder M, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz J, Andreasson K. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63. PMCID: PMC6768398

Rodriguez A, Ducker G, Billingham L, Martinez C, Mainolfi N, Suri V, Friedman A, Manfredi M, Weinberg S, Rabinowitz J, Chandel N. Serine Metabolism Supports Macrophage IL-1β Production. Cell Metab. 2019;29(4):1003–1011.e4. PMCID: PMC6447453

Ron-Harel N, Notarangelo G, Ghergurovich J, Paulo J, Sage P, Santos D, Satterstrom K, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347–13352. PMCID: PMC6310842

Bradley P, Gibney P, Botstein D, Troyanskaya O, Rabinowitz J. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. mSystems. 2019;4(1). PMCID: PMC6392091

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg M, Mehnert J, Guo J, Lattime E, Rabinowitz J, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569–573. PMCID: PMC6287937

Neinast M, Jang C, Hui S, Murashige D, Chu Q, Morscher R, Li X, Zhan L, White E, Anthony T, Rabinowitz J, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019;29(2):417–429.e4. PMCID: PMC6365191

Xu Y-F, Lu W, Chen J, Johnson S, Gibney P, Thomas D, Brown G, May A, Campagna S, Yakunin A, Botstein D, Rabinowitz J. Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase. ACS Chem Biol. 2018;13(10):3011–3020. PMCID: PMC6466636

Tanner L, Goglia A, Wei M, Sehgal T, Parsons L, Park J, White E, Toettcher J, Rabinowitz J. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018;7(1):49–62.e8. PMCID: PMC6062487

Rodan L, Qi W, Ducker G, Demirbas D, Laine R, Yang E, Walker M, Eichler F, Rabinowitz J, Anselm I, Berry G, Undiagnosed Diseases Network (UDN). 5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Mol Genet Metab. 2018;125(1-2):118–126. PMCID: PMC6557438

Guan D, Xiong Y, Borck P, Jang C, Doulias P-T, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs E, Hu W, Steger D, Ischiropoulos H, Rabinowitz J, Lazar M. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018;174(4):831–842.e12. PMCID: PMC6086765

Li S, Li Z, Park J, King C, Rabinowitz J, Wingreen N, Gitai Z. Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nat Microbiol. 2018;3(8):939–947. PMCID: PMC6278830

Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella L, Zhang Z, Migaud M, Rabinowitz J, Baur J. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018;7. PMCID: PMC6013257

Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(9):1482. PMID: 29895835

Zhang Z, Chen L, Liu L, Su X, Rabinowitz J. Chemical Basis for Deuterium Labeling of Fat and NADPH. J Am Chem Soc. 2017;139(41):14368–14371. PMCID: PMC5748894

Jang C, Chen L, Rabinowitz J. Metabolomics and Isotope Tracing. Cell. 2018;173(4):822–837. PMCID: PMC6034115

Nofal M, Rabinowitz J. Ribosomes on the night shift. Science. 2018;360(6390):710–711. PMID: 29773733

Liu L, Su X, Quinn W, Hui S, Krukenberg K, Frederick D, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison T, Baur J, Rabinowitz J. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018;27(5):1067–1080.e5. PMCID: PMC5932087

Lin K-C, Torga G, Wu A, Rabinowitz J, Murray W, Sturm J, Pienta K, Austin R. Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg Sci Phys Oncol. 2017;3(4). PMCID: PMC5840799

Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(4):518–524. PMCID: PMC6089616

Gibney P, Schieler A, Chen J, Bacha-Hummel J, Botstein M, Volpe M, Silverman S, Xu Y, Bennett B, Rabinowitz J, Botstein D. Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol Biol Cell. 2018;29(8):897–910. PMCID: PMC5896929

Jang C, Hui S, Lu W, Cowan A, Morscher R, Lee G, Liu W, Tesz G, Birnbaum M, Rabinowitz J. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018;27(2):351–361.e3. PMCID: PMC6032988

McKee S, Zhang S, Chen L, Rabinowitz J, Reyes T. Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J Neurochem. 2018;145(5):362–373. PMCID: PMC6288810