1.Wu Z-Y, Sun W, Shen Y, Pratas J, Suthers P, Hsieh P-H, Dwaraknath S, Rabinowitz J, Maranas C, Shao Z, Yoshikuni Y. Metabolic engineering of low-pH-tolerant non-model yeast, , for production of citramalate. Metab Eng Commun. 2023;16:e00220. PMCID: PMC9969067 Reference Link
1.Flam E, Jang C, Murashige D, Yang Y, Morley M, Jung S, Kantner D, Pepper H, Bedi K, Brandimarto J, Prosser B, Cappola T, Snyder N, Rabinowitz J, Margulies K, Arany Z. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat Cardiovasc Res. 2022;1(9):817–829. PMCID: PMC9910091 Reference Link
1.McBride M, Hunter C, Rabinowitz J. Glycine homeostasis requires reverse SHMT flux. bioRxiv. 2023;. PMCID: PMC9882094 Reference Link
1.Bartman C, Weilandt D, Shen Y, Lee W, Han Y, TeSlaa T, Jankowski C, Samarah L, Park N, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Heiden M, Herranz D, Guo J, Kang Y, Rabinowitz J. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023;614(7947):349–357. PMID: 36725930 Reference Link
1.Hu M, Dinh H, Shen Y, Suthers P, Foster C, Call C, Ye X, Pratas J, Fatma Z, Zhao H, Rabinowitz J, Maranas C. Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale. Metab Eng. 2023;76:1–17. PMID: 36603705 Reference Link
1.Chellappa K, McReynolds M, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat Y, Lingala S, Shima R, Descamps H, Cox T, Ji L, Jankowski C, Chu Q, Davidson S, Thaiss C, Migaud M, Rabinowitz J, Baur J. NAD precursors cycle between host tissues and the gut microbiome. Cell Metab. 2022;34(12):1947–1959.e5. PMCID: PMC9825113 Reference Link
1.Meyer C, Seath C, Knutson S, Lu W, Rabinowitz J, MacMillan D. Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. J Am Chem Soc. 2022;144(51):23633–23641. PMID: 36525649 Reference Link
1.Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng A, Zhang Y, Frederick D, Gu L, Cai L, Asara J, di Magliano M, Boland G, Flaherty K, Swanson K, Liu D, Rabinowitz J, Zheng B. Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth. Nat Metab. 2022;4(12):1660–1673. PMID: 36376563 Reference Link
1.Murashige D, Jung J, Neinast M, Levin M, Chu Q, Lambert J, Garbincius J, Kim B, Hoshino A, Marti-Pamies I, McDaid K, Shewale S, Flam E, Yang S, Roberts E, Li L, Morley M, Bedi K, Hyman M, Frankel D, Margulies K, Assoian R, Elrod J, Jang C, Rabinowitz J, Arany Z. Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metab. 2022;34(11):1749–1764.e7. PMCID: PMC9633425 Reference Link
1.Jang C, Hui S, Zeng X, Cowan A, Wang L, Chen L, Morscher R, Reyes J, Frezza C, Hwang H, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido G, Gorman J, Gorman R, Rabinowitz J. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2022;34(9):1410. PMCID: PMC9514224 Reference Link
1.Zeng X, Xing X, Gupta M, Keber F, Lopez J, Lee Y-C, Roichman A, Wang L, Neinast M, Donia M, Wühr M, Jang C, Rabinowitz J. Gut bacterial nutrient preferences quantified in vivo. Cell. 2022;185(18):3441–3456.e19. PMCID: PMC9450212 Reference Link
1.Jankowski C, Rabinowitz J. Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate. Cancer Res. 2022;82(19):3486–3498. PMCID: PMC9532358 Reference Link
1.Xiao T, Khan A, Shen Y, Chen L, Rabinowitz J. Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast. Nat Chem Biol. 2022;18(12):1380–1387. PMCID: 1082793 Reference Link
1.Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown E, Stanger B, Rabinowitz J, Yang X. G6PD-mediated increase in de novo NADP biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv. 2022;8(29):eabo0404. PMCID: PMC9299539 Reference Link
1.Lindell R, Zhang D, Bush J, Wallace D, Rabinowitz J, Lu W, Wherry J, Weiss S, Henrickson S. Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock. 2022;57(6):191–199. PMCID: PMC9245144 Reference Link
1.Yang L, TeSlaa T, Ng S, Nofal M, Wang L, Lan T, Zeng X, Cowan A, McBride M, Lu W, Davidson S, Liang G, Oh T, Downes M, Evans R, Von Hoff D, Guo J, Han H, Rabinowitz J. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med. 2022;3(2):119–136. PMCID: PMC9004683 Reference Link
1.Poillet-Perez L, Sharp D, Yang Y, Laddha S, Ibrahim M, Bommareddy P, Hu Z, Vieth J, Haas M, Bosenberg M, Rabinowitz J, Cao J, Guan J-L, Ganesan S, Chan C, Mehnert J, Lattime E, White E. Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2021;2(9):994. PMID: 35121870 Reference Link
1.Wang L, Xing X, Zeng X, Jackson R, TeSlaa T, Al-Dalahmah O, Samarah L, Goodwin K, Yang L, McReynolds M, Li X, Wolff J, Rabinowitz J, Davidson S. Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods. 2022;19(2):223–230. PMID: 35132243 Reference Link
1.Li X, Hui S, Mirek E, Jonsson W, Anthony T, Lee W, Zeng X, Jang C, Rabinowitz J. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022;4(1):141–152. PMCID: PMC9244777 Reference Link
1.Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, García-Cañaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55(1):65–81.e9. PMCID: PMC8755618 Reference Link
1.Ding H, Chen Z, Wu K, Huang S, Wu W, LeBoeuf S, Pillai R, Rabinowitz J, Papagiannakopoulos T. Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv. 2021;7(47):eabk1023. PMCID: PMC8598006 Reference Link
1.Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419 Reference Link
1.Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747 Reference Link
1.Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021;18(11):1377–1385. PMCID: PMC8733904 Reference Link
1.Olszewski K, Barsotti A, Feng X-J, Momcilovic M, Liu K, Kim J-I, Morris K, Lamarque C, Gaffney J, Yu X, Patel J, Rabinowitz J, Shackelford D, Poyurovsky M. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022;29(3):423–435.e10. PMID: 34715056 Reference Link
1.Nofal M, Wang T, Yang L, Jankowski C, Li S, Han S, Parsons L, Frese A, Gitai Z, Anthony T, Wühr M, Sabatini D, Rabinowitz J. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst. 2022;13(2):158–172.e9. PMCID: PMC8961722 Reference Link
1.Wilke A, Doebele C, Zindel A, Lee K, Rieke S, Ceribelli M, Comoglio F, Phelan J, Wang J, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto F, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly Z, Wolf S, Bojarczuk K, Chapuy B, Brandts C, Stroebel P, Lewis C, Engelke M, Xu X, Kim H, Dang T, Schmitz R, Hodson D, Stegmaier K, Urlaub H, Serve H, Schmitt C, Kreuz F, Knittel G, Rabinowitz J, Reinhardt H, Heiden M, Thomas C, Staudt L, Zenz T, Oellerich T. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538–553. PMCID: PMC8938936 Reference Link
1.McReynolds M, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps H, Mukherjee S, Bhat Y, Lingala S, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss C, Lu W, Migaud M, Su X, Rabinowitz J, Baur J. NAD flux is maintained in aged mice despite lower tissue concentrations. Cell Syst. 2021;12(12):1160–1172.e4. PMCID: PMC8678178 Reference Link
1.García-Cañaveras J, Heo D, Trefely S, Leferovich J, Xu C, Philipson B, Ghassemi S, Milone M, Moon E, Snyder N, June C, Rabinowitz J, O’Connor R. CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells. 2021;10(9). PMCID: PMC8472053 Reference Link
1.Parkhitko A, Wang L, Filine E, Jouandin P, Leshchiner D, Binari R, Asara J, Rabinowitz J, Perrimon N. A genetic model of methionine restriction extends health- and lifespan. Proc Natl Acad Sci U S A. 2021;118(40). PMCID: PMC8501845 Reference Link
1.Poillet-Perez L, Sharp D, Yang Y, Laddha S, Ibrahim M, Bommareddy P, Hu Z, Vieth J, Haas M, Bosenberg M, Rabinowitz J, Cao J, Guan J-L, Ganesan S, Chan C, Mehnert J, Lattime E, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020;1(9):923–934. PMCID: PMC8409526 Reference Link
1.Cable J, Pourquié O, Wellen K, Finley L, Aulehla A, Gould A, Teleman A, Tu W, Garrett W, Miguel-Aliaga I, Perrimon N, Hooper L, Walhout A, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz J, Hemalatha A, Gutiérrez-Pérez P, Chandel N, Rutter J, Locasale J, Landoni J, Christofk H. Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021;1506(1):55–73. PMID: 34414571 Reference Link
1.Phan T, Nguyen V, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar M, Gil Z, Diamond D, Rabinowitz J, Rosen S, Melstrom L. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int J Biol Sci. 2021;17(9):2240–2251. PMCID: PMC8241727 Reference Link
1.Schild T, McReynolds M, Shea C, Low V, Schaffer B, Asara J, Piskounova E, Dephoure N, Rabinowitz J, Gomes A, Blenis J. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021;35(11):109238. PMID: 34133937 Reference Link
1.Ghergurovich J, Lang J, Levin M, Briones N, Facista S, Mueller C, Cowan A, McBride M, Rodriguez E, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks W, Espina V, Von Hoff D, O’Shaughnessy J, Rabinowitz J. Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med. 2021;2(6):736–754. PMCID: PMC8248508 Reference Link
1.Bartman C, TeSlaa T, Rabinowitz J. Quantitative flux analysis in mammals. Nat Metab. 2021;3(7):896–908. PMCID: PMC9289955 Reference Link
1.Li S, Nofal M, Parsons L, Rabinowitz J, Gitai Z. Monitoring mammalian mitochondrial translation with MitoRiboSeq. Nat Protoc. 2021;16(6):2802–2825. PMCID: PMC8610098 Reference Link
1.Yu D, Richardson N, Green C, Spicer A, Murphy M, Flores V, Jang C, Kasza I, Nikodemova M, Wakai M, Tomasiewicz J, Yang S, Miller B, Pak H, Brinkman J, Rojas J, Quinn W, Cheng E, Konon E, Haider L, Finke M, Sonsalla M, Alexander C, Rabinowitz J, Baur J, Malecki K, Lamming D. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab. 2021;33(5):905–922.e6. PMCID: PMC8102360 Reference Link
1.Cho S, Lee G, Pickering B, Jang C, Park J, He L, Mathur L, Kim S-S, Jung S, Tang H-W, Monette S, Rabinowitz J, Perrimon N, Jaffrey S, Blenis J. mTORC1 promotes cell growth via mA-dependent mRNA degradation. Mol Cell. 2021;81(10):2064–2075.e8. PMCID: PMC8356906 Reference Link
1.TeSlaa T, Bartman C, Jankowski C, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz J. The Source of Glycolytic Intermediates in Mammalian Tissues. Cell Metab. 2021;33(2):367–378.e5. PMCID: PMC8088818 Reference Link
1.Minhas P, Latif-Hernandez A, McReynolds M, Durairaj A, Wang Q, Rubin A, Joshi A, He J, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon P, Majeti R, Suematsu M, Mochly-Rosen D, Weissman I, Longo F, Rabinowitz J, Andreasson K. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021;590(7844):122–128. PMCID: PMC8274816 Reference Link
1.Ringel A, Drijvers J, Baker G, Catozzi A, García-Cañaveras J, Gassaway B, Miller B, Juneja V, Nguyen T, Joshi S, Yao C-H, Yoon H, Sage P, LaFleur M, Trombley J, Jacobson C, Maliga Z, Gygi S, Sorger P, Rabinowitz J, Sharpe A, Haigis M. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848–1866.e26. PMCID: PMC8064125 Reference Link
1.Parkhitko A, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen A, Asara J, Cracan V, Rabinowitz J, Brockmann A, Perrimon N. Downregulation of the tyrosine degradation pathway extends lifespan. Elife. 2020;9. PMCID: PMC7744100 Reference Link
1.Chini C, Peclat T, Warner G, Kashyap S, Espindola-Netto J, de Oliveira G, Gomez L, Hogan K, Tarragó M, Puranik A, Agorrody G, Thompson K, Dang K, Clarke S, Childs B, Kanamori K, Witte M, Vidal P, Kirkland A, De Cecco M, Chellappa K, McReynolds M, Jankowski C, Tchkonia T, Kirkland J, Sedivy J, van Deursen J, Baker D, van Schooten W, Rabinowitz J, Baur J, Chini E. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020;2(11):1284–1304. PMCID: PMC8752031 Reference Link
1.Zhang Y, Xu Y, Lu W, Ghergurovich J, Guo L, Blair I, Rabinowitz J, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94–109.e8. PMCID: PMC7846267 Reference Link
1.Suthers P, Dinh H, Fatma Z, Shen Y, Chan S, Rabinowitz J, Zhao H, Maranas C. Genome-scale metabolic reconstruction of the non-model yeast SD108 and its application to organic acids production. Metab Eng Commun. 2020;11:e00148. PMCID: PMC7586132 Reference Link
1.Murashige D, Jang C, Neinast M, Edwards J, Cowan A, Hyman M, Rabinowitz J, Frankel D, Arany Z. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020;370(6514):364–368. PMCID: PMC7871704 Reference Link
1.Luongo T, Eller J, Lu M-J, Niere M, Raith F, Perry C, Bornstein M, Oliphint P, Wang L, McReynolds M, Migaud M, Rabinowitz J, Johnson B, Johnsson K, Ziegler M, Cambronne X, Baur J. SLC25A51 is a mammalian mitochondrial NAD transporter. Nature. 2020;588(7836):174–179. PMCID: PMC7718333 Reference Link
1.Green R, Wang L, Hart S, Lu W, Skelding D, Burton J, Mi H, Capel A, Chen H, Lin A, Subramaniam A, Rabinowitz J, Shou W. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol. 2020;18(8):e3000757. PMCID: PMC7470746 Reference Link
1.Hui S, Cowan A, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz J. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020;32(4):676–688.e4. PMCID: PMC7544659 Reference Link