1.Wu X, Yan R, Cao P, Qian H, Yan N. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022;47(4):289–300. PMID: 35012873 Reference Link
1.Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021;35(13):109299. PMID: 34192549 Reference Link
1.Yan R, Cao P, Song W, Qian H, Du X, Coates H, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown A, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021;371(6533). PMID: 33446483 Reference Link
1.Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020;182(1):98–111.e18. PMID: 32544384 Reference Link
1.Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad B, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020;581(7808):329–332. PMCID: PMC7255049 Reference Link
1.Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong C, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020;581(7808):333–338. PMCID: 5093084 Reference Link
1.Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019;10(1):2320. PMCID: PMC6534611 Reference Link
1.Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018;47(2):248–256.e4. PMID: 30293840 Reference Link
1.Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018;361(6402). PMID: 29954986 Reference Link
1.Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res. 2015;25(4):401–11. PMCID: PMC4387560 Reference Link
1.Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, Li W, Wang H-W, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016;26(11):1197–1211. PMCID: PMC5099872 Reference Link
1.Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239.e10. PMID: 28602350 Reference Link
