Lukasak B, Mitchener M, Kong L, Dul B, Lazarus C, Ramakrishnan A, Ni J, Shen L, Maze I, Muir T. TGM2-mediated histone transglutamination is dictated by steric accessibility. Proc Natl Acad Sci U S A. 2022;119(43):e2208672119. PMCID: PMC9618071

Sekar G, Stevens A, Mostafavi A, Sashi P, Muir T, Cowburn D. A Conserved Histidine Residue Drives Extein Dependence in an Enhanced Atypically Split Intein. J Am Chem Soc. 2022;144(41):19196–19203. PMID: 36194550

Mitchener M, Muir T. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022;82(16):2925–2938. PMCID: PMC9482148

Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, Muir T. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022;119(33):e2202661119. PMCID: PMC9388083

Lukasak B, Thompson R, Mitchener M, Feng V, Bagert J, Muir T. A Genetically Encoded Approach for Breaking Chromatin Symmetry. ACS Cent Sci. 2022;8(2):176–183. PMCID: PMC8875426

Dao H, Liu H, Mashtalir N, Kadoch C, Muir T. Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. J Am Chem Soc. 2022;144(5):2284–2291. PMCID: PMC8935522

Burton A, Hamza G, Zhang A, Muir T. Chemical biology approaches to study histone interactors. Biochem Soc Trans. 2021;49(5):2431–2441. PMCID: PMC9785950

Mashtalir N, Dao H, Sankar A, Liu H, Corin A, Bagert J, Ge E, D’Avino A, Filipovski M, Michel B, Dann G, Muir T, Kadoch C. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021;373(6552):306–315. PMCID: PMC8390793

Mitchener M, Muir T. Janus Bioparticles: Asymmetric Nucleosomes and Their Preparation Using Chemical Biology Approaches. Acc Chem Res. 2021;54(16):3215–3227. PMCID: PMC8411803

Hananya N, Daley S, Bagert J, Muir T. Synthesis of ADP-Ribosylated Histones Reveals Site-Specific Impacts on Chromatin Structure and Function. J Am Chem Soc. 2021;143(29):10847–10852. PMID: 34264659

Song H, Burton A, Shirran S, Fahrig-Kamarauskaitė J, Kaspar H, Muir T, Künzler M, Naismith J. Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids. Angew Chem Int Ed Engl. 2021;60(26):14319–14323. PMCID: PMC8251615

Zhao S, Chuh K, Zhang B, Dul B, Thompson R, Farrelly L, Liu X, Xu N, Xue Y, Roeder R, Maze I, Muir T, Li H. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021;118(6). PMCID: PMC8017887

Bagert J, Muir T. Molecular Epigenetics: Chemical Biology Tools Come of Age. Annu Rev Biochem. 2021;90:287–320. PMCID: PMC8284505

Wu A, Zhi J, Tian T, Cihan A, Cevher M, Liu Z, David Y, Muir T, Roeder R, Yu M. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021;118(27). PMCID: PMC8271641

Bagert J, Mitchener M, Patriotis A, Dul B, Wojcik F, Nacev B, Feng L, Allis D, Muir T. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021;17(4):403–411. PMCID: PMC8174649

Seath C, Trowbridge A, Muir T, MacMillan D. Reactive intermediates for interactome mapping. Chem Soc Rev. 2021;50(5):2911–2926. PMID: 33458734

Leicher R, Ge E, Lin X, Reynolds M, Xie W, Walz T, Zhang B, Muir T, Liu S. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020;117(48):30465–30475. PMCID: PMC7720148

McBride M, Mashtalir N, Winter E, Dao H, Filipovski M, D’Avino A, Seo H-S, Umbreit N, St Pierre R, Valencia A, Qian K, Zullow H, Jaffe J, Dhe-Paganon S, Muir T, Kadoch C. Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2021;28(1):118. PMCID: PMC7801252

McBride M, Mashtalir N, Winter E, Dao H, Filipovski M, D’Avino A, Seo H-S, Umbreit N, St Pierre R, Valencia A, Qian K, Zullow H, Jaffe J, Dhe-Paganon S, Muir T, Kadoch C. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020;27(9):836–845. PMCID: PMC7714695

Xie Q, Wiedmann M, Zhao A, Pagan I, Novick R, Suga H, Muir T. Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC. Chem Commun (Camb). 2020;56(76):11223–11226. PMCID: PMC7530097

Murawska M, Schauer T, Matsuda A, Wilson M, Pysik T, Wojcik F, Muir T, Hiraoka Y, Straub T, Ladurner A. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020;77(3):501–513.e7. PMCID: PMC7007867

Diehl K, Muir T. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020;16(6):620–629. PMCID: PMC7258299

Burton A, Haugbro M, Gates L, Bagert J, Allis D, Muir T. In situ chromatin interactomics using a chemical bait and trap approach. Nat Chem. 2020;12(6):520–527. PMCID: PMC7331920

Dao H, Dul B, Dann G, Liszczak G, Muir T. A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nat Chem Biol. 2020;16(2):134–142. PMCID: PMC6982587

Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll T, Li Y, Feng L, Chen G, Wang S-P, Ortiz M, Daley S, Wang X, Xuan H, Kentsis A, Muir T, Roeder R, Li H, Li W, Tjian R, Wen H, Allis D. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2020;577(7788):121–126. PMCID: PMC7061414

Ge E, Jani K, Diehl K, Müller M, Muir T. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. J Am Chem Soc. 2019;141(38):15029–15039. PMCID: PMC6941475

Diehl K, Ge E, Weinberg D, Jani K, Allis D, Muir T. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proc Natl Acad Sci U S A. 2019;116(44):22152–22157. PMCID: PMC6825254

Valencia A, Collings C, Dao H, St Pierre R, Cheng Y-C, Huang J, Sun Z-Y, Seo H-S, Mashtalir N, Comstock D, Bolonduro O, Vangos N, Yeoh Z, Dornon M, Hermawan C, Barrett L, Dhe-Paganon S, Woolf C, Muir T, Kadoch C. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019;179(6):1342–1356.e23. PMCID: PMC7175411

Albig C, Wang C, Dann G, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir T, Johansen J, Johansen K, Becker P, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019;10(1):5343. PMCID: PMC6877644

Thompson R, Muir T. Chemoenzymatic Semisynthesis of Proteins. Chem Rev. 2020;120(6):3051–3126. PMCID: PMC7101271

Stevens A, Sekar G, Gramespacher J, Cowburn D, Muir T. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J Am Chem Soc. 2018;140(37):11791–11799. PMCID: PMC7232844

Thompson R, Stevens A, Muir T. Protein engineering through tandem transamidation. Nat Chem. 2019;11(8):737–743. PMCID: PMC6711197

Guerra L, Muir T, Yang H. Single-Particle Dynamic Light Scattering: Shapes of Individual Nanoparticles. Nano Lett. 2019;19(8):5530–5536. PMID: 31272153

Gramespacher J, Burton A, Guerra L, Muir T. Proximity Induced Splicing Utilizing Caged Split Inteins. J Am Chem Soc. 2019;141(35):13708–13712. PMCID: PMC6903685

Beh L, Debelouchina G, Clay D, Thompson R, Lindblad K, Hutton E, Bracht J, Sebra R, Muir T, Landweber L. Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization. Cell. 2019;177(7):1781–1796.e25. PMCID: PMC6570567

Jain S, Do T, Lund P, Rashoff A, Diehl K, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir T, Garcia B, Jabado N, Lewis P. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019;10(1):2146. PMCID: PMC6513997

Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, Zhang B, Loh Y-H, Ramakrishnan A, Vadodaria K, Heard K, Erikson G, Nakadai T, Bastle R, Lukasak B, Zebroski H, Alenina N, Bader M, Berton O, Roeder R, Molina H, Gage F, Shen L, Garcia B, Li H, Muir T, Maze I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535–539. PMCID: PMC6557285

Nacev B, Feng L, Bagert J, Lemiesz A, Gao J, Soshnev A, Kundra R, Schultz N, Muir T, Allis D. The expanding landscape of ’oncohistone’ mutations in human cancers. Nature. 2019;567(7749):473–478. PMCID: PMC6512987

Jani K, Jain S, Ge E, Diehl K, Lundgren S, Müller M, Lewis P, Muir T. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A. 2019;116(17):8295–8300. PMCID: PMC6486736

Xie Q, Zhao A, Jeffrey P, Kim M, Bassler B, Stone H, Novick R, Muir T. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019;26(4):548–558.e4. PMCID: PMC6506218

Jeon J, McGinty R, Muir T, Kim J-A, Kim J. Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation. Nucleic Acids Res. 2018;46(21):11129–11143. PMCID: PMC6265457

Liszczak G, Muir T. Nucleic Acid-Barcoding Technologies: Converting DNA Sequencing into a Broad-Spectrum Molecular Counter. Angew Chem Int Ed Engl. 2019;58(13):4144–4162. PMCID: PMC6748390

Liszczak G, Diehl K, Dann G, Muir T. Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. Nat Chem Biol. 2018;14(9):837–840. PMCID: PMC6505472

Bos J, Muir T. A Chemical Probe for Protein Crotonylation. J Am Chem Soc. 2018;140(14):4757–4760. PMCID: PMC6505473

Wojcik F, Dann G, Beh L, Debelouchina G, Hofmann R, Muir T. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018;9(1):1394. PMCID: PMC5895630

Gramespacher J, Stevens A, Nguyen D, Chin J, Muir T. Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis. J Am Chem Soc. 2017;139(24):8074–8077. PMCID: PMC5533455

Aebersold R, Agar J, Amster J, Baker M, Bertozzi C, Boja E, Costello C, Cravatt B, Fenselau C, Garcia B, Ge Y, Gunawardena J, Hendrickson R, Hergenrother P, Huber C, Ivanov A, Jensen O, Jewett M, Kelleher N, Kiessling L, Krogan N, Larsen M, Loo J, Loo R, Lundberg E, MacCoss M, Mallick P, Mootha V, Mrksich M, Muir T, Patrie S, Pesavento J, Pitteri S, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff S, Smith L, Snyder M, Thomas P, Uhlén M, Van Eyk J, Vidal M, Walt D, White F, Williams E, Wohlschlager T, Wysocki V, Yates N, Young N, Zhang B. How many human proteoforms are there?. Nat Chem Biol. 2018;14(3):206–214. PMCID: PMC5837046

Jenness C, Giunta S, Müller M, Kimura H, Muir T, Funabiki H. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proc Natl Acad Sci U S A. 2018;115(5):E876-E885. PMCID: PMC5798369

Debelouchina G, Muir T. A molecular engineering toolbox for the structural biologist. Q Rev Biophys. 2017;50:e7. PMCID: PMC5978726

Gramespacher J, Stevens A, Thompson R, Muir T. Improved protein splicing using embedded split inteins. Protein Sci. 2018;27(3):614–619. PMCID: PMC5818749