1.Bartman C, Weilandt D, Shen Y, Lee W, Han Y, TeSlaa T, Jankowski C, Samarah L, Park N, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Heiden M, Herranz D, Guo J, Kang Y, Rabinowitz J. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023;614(7947):349–357. PMID: 36725930 Reference Link
1.Chellappa K, McReynolds M, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat Y, Lingala S, Shima R, Descamps H, Cox T, Ji L, Jankowski C, Chu Q, Davidson S, Thaiss C, Migaud M, Rabinowitz J, Baur J. NAD precursors cycle between host tissues and the gut microbiome. Cell Metab. 2022;34(12):1947–1959.e5. PMCID: PMC9825113 Reference Link
1.Meyer C, Seath C, Knutson S, Lu W, Rabinowitz J, MacMillan D. Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. J Am Chem Soc. 2022;144(51):23633–23641. PMID: 36525649 Reference Link
1.Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown E, Stanger B, Rabinowitz J, Yang X. G6PD-mediated increase in de novo NADP biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv. 2022;8(29):eabo0404. PMCID: PMC9299539 Reference Link
1.Lindell R, Zhang D, Bush J, Wallace D, Rabinowitz J, Lu W, Wherry J, Weiss S, Henrickson S. Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock. 2022;57(6):191–199. PMCID: PMC9245144 Reference Link
1.Yang L, TeSlaa T, Ng S, Nofal M, Wang L, Lan T, Zeng X, Cowan A, McBride M, Lu W, Davidson S, Liang G, Oh T, Downes M, Evans R, Von Hoff D, Guo J, Han H, Rabinowitz J. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med. 2022;3(2):119–136. PMCID: PMC9004683 Reference Link
1.Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021;18(11):1377–1385. PMCID: PMC8733904 Reference Link
1.McReynolds M, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps H, Mukherjee S, Bhat Y, Lingala S, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss C, Lu W, Migaud M, Su X, Rabinowitz J, Baur J. NAD flux is maintained in aged mice despite lower tissue concentrations. Cell Syst. 2021;12(12):1160–1172.e4. PMCID: PMC8678178 Reference Link
1.TeSlaa T, Bartman C, Jankowski C, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz J. The Source of Glycolytic Intermediates in Mammalian Tissues. Cell Metab. 2021;33(2):367–378.e5. PMCID: PMC8088818 Reference Link
1.Zhang Y, Xu Y, Lu W, Ghergurovich J, Guo L, Blair I, Rabinowitz J, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94–109.e8. PMCID: PMC7846267 Reference Link
1.Green R, Wang L, Hart S, Lu W, Skelding D, Burton J, Mi H, Capel A, Chen H, Lin A, Subramaniam A, Rabinowitz J, Shou W. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol. 2020;18(8):e3000757. PMCID: PMC7470746 Reference Link
1.Hui S, Cowan A, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz J. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020;32(4):676–688.e4. PMCID: PMC7544659 Reference Link
1.Su X, Lu W, Rabinowitz J. Metabolite Spectral Accuracy on Orbitraps. Anal Chem. 2017;89(11):5940–5948. PMCID: PMC5748891 Reference Link
1.Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg M, Mehnert J, Guo J, Lattime E, Rabinowitz J, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569–573. PMCID: PMC6287937 Reference Link
1.Xu Y-F, Lu W, Chen J, Johnson S, Gibney P, Thomas D, Brown G, May A, Campagna S, Yakunin A, Botstein D, Rabinowitz J. Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase. ACS Chem Biol. 2018;13(10):3011–3020. PMCID: PMC6466636 Reference Link
1.Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(9):1482. PMID: 29895835 Reference Link
1.Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(4):518–524. PMCID: PMC6089616 Reference Link
1.Jang C, Hui S, Lu W, Cowan A, Morscher R, Lee G, Liu W, Tesz G, Birnbaum M, Rabinowitz J. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018;27(2):351–361.e3. PMCID: PMC6032988 Reference Link
1.Liu L, Rowe G, Yang S, Li J, Damilano F, Chan M, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann B, Rabinowitz J, Das S, Rosenzweig A, Arany Z. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017;121(12):1370–1378. PMCID: PMC5722682 Reference Link
1.Hui S, Ghergurovich J, Morscher R, Jang C, Teng X, Lu W, Esparza L, Reya T, Guo J, White E, Rabinowitz J. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115–118. PMCID: PMC5898814 Reference Link
1.Kim H, Raffler J, Lu W, Lee J-J, Abbey D, Saleheen D, Rabinowitz J, Bennett M, Hand N, Brown C, Rader D. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017;101(4):489–502. PMCID: PMC5630162 Reference Link
1.Wooldridge A, Bischof R, Liu H, Heinemann G, Hunter D, Giles L, Simmons R, Lien Y-C, Lu W, Rabinowitz J, Kind K, Owens J, Clifton V, Gatford K. Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am J Physiol Regul Integr Comp Physiol. 2018;314(1):R22-R33. PMCID: PMC5866368 Reference Link
1.Chen L, Ducker G, Lu W, Teng X, Rabinowitz J. An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate. Anal Bioanal Chem. 2017;409(25):5955–5964. PMCID: PMC5737010 Reference Link
1.Lu W, Wang L, Chen L, Hui S, Rabinowitz J. Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors. Antioxid Redox Signal. 2018;28(3):167–179. PMCID: PMC5737638 Reference Link
1.Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang C, Qian J, Lie N, Lanzillotta C, Rabinowitz J, Sun Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018;471:22–32. PMCID: PMC5702591 Reference Link
1.Lu W, Su X, Klein M, Lewis I, Fiehn O, Rabinowitz J. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annu Rev Biochem. 2017;86:277–304. PMCID: PMC5734093 Reference Link
1.Titchenell P, Quinn W, Lu M, Chu Q, Lu W, Li C, Chen H, Monks B, Chen J, Rabinowitz J, Birnbaum M. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016;23(6):1154–1166. PMCID: PMC4909537 Reference Link
1.Koivunen P, Fell S, Lu W, Rabinowitz J, Kung A, Schlisio S. The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia (Auckl). 2016;4:15–27. PMCID: PMC4981084 Reference Link
1.Papazyan R, Sun Z, Kim Y, Titchenell P, Hill D, Lu W, Damle M, Wan M, Zhang Y, Briggs E, Rabinowitz J, Lazar M. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016;24(6):863–874. PMCID: PMC5159233 Reference Link
1.Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill B, Molina H, Khurana T, Rabinowitz J, Lazar M, Sun Z. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017;23(2):223–234. PMCID: PMC5540654 Reference Link
1.Xavier K, Miller S, Lu W, Kim J, Rabinowitz J, Pelczer I, Semmelhack M, Bassler B. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol. 2007;2(2):128–36. PMID: 17274596 Reference Link
1.Waters C, Lu W, Rabinowitz J, Bassler B. Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol. 2008;190(7):2527–36. PMCID: PMC2293178 Reference Link
1.Kelly R, Bolitho M, Higgins D, Lu W, Ng W-L, Jeffrey P, Rabinowitz J, Semmelhack M, Hughson F, Bassler B. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol. 2009;5(12):891–5. PMCID: PMC2847429 Reference Link