1.Taylor I, Jeffrey P, Moustafa D, Goldberg J, Bassler B. The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against . Biochemistry. 2022;61(17):1894–1903. PMCID: PMC9454246 Reference Link
1.Du J, Estrella M, Solorio-Kirpichyan K, Jeffrey P, Korennykh A. Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proc Natl Acad Sci U S A. 2022;119(26):e2200923119. PMCID: PMC9245612 Reference Link
1.Balaich J, Estrella M, Wu G, Jeffrey P, Biswas A, Zhao L, Korennykh A, Donia M. The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature. 2021;600(7887):110–115. PMCID: 3552296 Reference Link
1.Taylor I, Paczkowski J, Jeffrey P, Henke B, Smith C, Bassler B. Inhibitor Mimetic Mutations in the PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021;16(4):740–752. PMCID: PMC8056388 Reference Link
1.He S, Chou H-T, Matthies D, Wunder T, Meyer M, Atkinson N, Martinez-Sanchez A, Jeffrey P, Port S, Patena W, He G, Chen V, Hughson F, McCormick A, Mueller-Cajar O, Engel B, Yu Z, Jonikas M. The structural basis of Rubisco phase separation in the pyrenoid. Nat Plants. 2020;6(12):1480–1490. PMCID: PMC7736253 Reference Link
1.Eisemann T, Allen F, Lau K, Shimamura G, Jeffrey P, Hughson F. The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation. Elife. 2020;9. PMCID: PMC7470827 Reference Link
1.Travis S, DAmico K, Yu I-M, McMahon C, Hamid S, Ramirez-Arellano G, Jeffrey P, Hughson F. Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. J Biol Chem. 2020;295(30):10125–10135. PMCID: PMC7383367 Reference Link
1.Sugimoto Y, Camacho F, Wang S, Chankhamjon P, Odabas A, Biswas A, Jeffrey P, Donia M. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Science. 2019;366(6471). PMID: 31582523 Reference Link
1.Xie Q, Zhao A, Jeffrey P, Kim M, Bassler B, Stone H, Novick R, Muir T. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019;26(4):548–558.e4. PMCID: PMC6506218 Reference Link
1.Paczkowski J, McCready A, Cong J-P, Li Z, Jeffrey P, Smith C, Henke B, Hughson F, Bassler B. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019;14(3):378–389. PMCID: PMC6601336 Reference Link
1.Piscotta F, Jeffrey P, Link J. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc Natl Acad Sci U S A. 2019;116(3):826–834. PMCID: PMC6338849 Reference Link
1.Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey P, Semmelhack M, Fairman R, Bassler B, Hughson F. Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biol. 2016;14(5):e1002464. PMCID: PMC4878744 Reference Link
1.Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey P, Hughson F, Glick B. Sec16 influences transitional ER sites by regulating rather than organizing COPII. Mol Biol Cell. 2013;24(21):3406–19. PMCID: PMC3814151 Reference Link
1.Ha J, Pokrovskaya I, Climer L, Shimamura G, Kudlyk T, Jeffrey P, Lupashin V, Hughson F. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proc Natl Acad Sci U S A. 2014;111(44):15762–7. PMCID: PMC4226102 Reference Link
1.Baker R, Jeffrey P, Zick M, Phillips B, Wickner W, Hughson F. A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science. 2015;349(6252):1111–4. PMCID: PMC4727825 Reference Link
1.Xing Y, Li Z, Chen Y, Stock J, Jeffrey P, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 2008;133(1):154–63. PMID: 18394995 Reference Link
1.Neiditch M, Federle M, Pompeani A, Kelly R, Swem D, Jeffrey P, Bassler B, Hughson F. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell. 2006;126(6):1095–108. PMCID: PMC3468944 Reference Link
1.Kelly R, Bolitho M, Higgins D, Lu W, Ng W-L, Jeffrey P, Rabinowitz J, Semmelhack M, Hughson F, Bassler B. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol. 2009;5(12):891–5. PMCID: PMC2847429 Reference Link
1.Chen G, Swem L, Swem D, Stauff D, O’Loughlin C, Jeffrey P, Bassler B, Hughson F. A strategy for antagonizing quorum sensing. Mol Cell. 2011;42(2):199–209. PMCID: PMC3092643 Reference Link