1.LeDesma R, Heller B, Biswas A, Maya S, Gili S, Higgins J, Ploss A. Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication. Elife. 2023;12. PMCID: PMC9977285 Reference Link
1.Wang R, Suzuki S, Guest J, Heller B, Almeda M, Andrianov A, Marin A, Mariuzza R, Keck Z-Y, Foung S, Yunus A, Pierce B, Toth E, Ploss A, Fuerst T. Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate. Proc Natl Acad Sci U S A. 2022;119(11):e2112008119. PMCID: PMC8931252 Reference Link
1.Gaska J, Balev M, Ding Q, Heller B, Ploss A. Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus. Elife. 2019;8. PMCID: PMC6510530 Reference Link
1.Douam F, Ziegler C, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska J, Winer B, Heller B, Shalek A, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018;9(1):5031. PMCID: PMC6262001 Reference Link
1.Winer B, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low B, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais M-A, Frankel A, Chiriboga L, Cullen J, Nahass R, Lutgehetmann M, Toettcher J, Wiles M, Schwartz R, Ploss A. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018;10(447). PMCID: PMC6337727 Reference Link
1.Ding Q, Gaska J, Douam F, Wei L, Kim D, Balev M, Heller B, Ploss A. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018;115(27):E6310-E6318. PMCID: PMC6142274 Reference Link
1.Ding Q, Nimgaonkar I, Archer N, Bram Y, Heller B, Schwartz R, Ploss A. Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. mBio. 2018;9(3). PMCID: PMC5941075 Reference Link
1.Winer B, Huang T, Pludwinski E, Heller B, Wojcik F, Lipkowitz G, Parekh A, Cho C, Shrirao A, Muir T, Novik E, Ploss A. Long-term hepatitis B infection in a scalable hepatic co-culture system. Nat Commun. 2017;8(1):125. PMCID: PMC5527081 Reference Link
1.Li D, Wang X, von Schaewen M, Tao W, Zhang Y, Heller B, Hrebikova G, Deng Q, Sun Q, Ploss A, Zhong J, Huang Z. Immunization With a Subunit Hepatitis C Virus Vaccine Elicits Pan-Genotypic Neutralizing Antibodies and Intrahepatic T-Cell Responses in Nonhuman Primates. J Infect Dis. 2017;215(12):1824–1831. PMCID: PMC5853543 Reference Link
1.von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz J, Gerold G, Suerbaum S, Rice C, Meuleman P, Pietschmann T, Ploss A. Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. mBio. 2016;7(6). PMCID: PMC5101358 Reference Link
1.Ding Q, von Schaewen M, Hrebikova G, Heller B, Sandmann L, Plaas M, Ploss A. Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo. J Virol. 2017;91(4). PMCID: PMC5286898 Reference Link
1.Ding Q, Heller B, Capuccino J, Song B, Nimgaonkar I, Hrebikova G, Contreras J, Ploss A. Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles. Proc Natl Acad Sci U S A. 2017;114(5):1147–1152. PMCID: PMC5293053 Reference Link
1.Li D, von Schaewen M, Wang X, Tao W, Zhang Y, Li L, Heller B, Hrebikova G, Deng Q, Ploss A, Zhong J, Huang Z. Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice. J Virol. 2016;90(23):10486–10498. PMCID: PMC5110194 Reference Link
1.Perin P, Haid S, Brown R, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash Y, Vondran F, Speerstra S, Awadh A, Mukhtarov F, Schang L, Kirschning A, Müller R, Guzman C, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T. Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology. 2016;63(1):49–62. PMCID: PMC4688136 Reference Link