1.Yan R, Cao P, Song W, Qian H, Du X, Coates H, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown A, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021;371(6533). PMID: 33446483 Reference Link
1.Thomas C, Aller S, Beis K, Carpenter E, Chang G, Chen L, Dassa E, Dean M, Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland B, Huang Y, Kahne D, Kato H, Koronakis V, Koth C, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett H, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng S-L, Slotboom D, Tajkhorshid E, Tieleman P, Ueda K, Váradi A, Wen P-C, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. Structural and functional diversity calls for a new classification of ABC transporters. FEBS Lett. 2020;594(23):3767–3775. PMCID: PMC8386196 Reference Link
1.Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019;10(1):2320. PMCID: PMC6534611 Reference Link
1.Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018;361(6402). PMID: 29954986 Reference Link
1.Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res. 2015;25(4):401–11. PMCID: PMC4387560 Reference Link
1.Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan F, Radhakrishnan A, Yan N. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 2015;349(6244):187–91. PMCID: PMC4704858 Reference Link
1.Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, Li W, Wang H-W, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016;26(11):1197–1211. PMCID: PMC5099872 Reference Link
1.Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239.e10. PMID: 28602350 Reference Link
