1.Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419 Reference Link
1.Ghergurovich J, Lang J, Levin M, Briones N, Facista S, Mueller C, Cowan A, McBride M, Rodriguez E, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks W, Espina V, Von Hoff D, O’Shaughnessy J, Rabinowitz J. Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med. 2021;2(6):736–754. PMCID: PMC8248508 Reference Link
1.Zhang Y, Xu Y, Lu W, Ghergurovich J, Guo L, Blair I, Rabinowitz J, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94–109.e8. PMCID: PMC7846267 Reference Link
1.Ghergurovich J, Esposito M, Chen Z, Wang J, Bhatt V, Lan T, White E, Kang Y, Guo J, Rabinowitz J. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020;80(18):3820–3829. PMCID: PMC7501231 Reference Link
1.García-Cañaveras J, Lancho O, Ducker G, Ghergurovich J, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz J. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35(2):377–388. PMCID: PMC7647950 Reference Link
1.Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271 Reference Link
1.Yang L, Canaveras J, Chen Z, Wang L, Liang L, Jang C, Mayr J, Zhang Z, Ghergurovich J, Zhan L, Joshi S, Hu Z, McReynolds M, Su X, White E, Morscher R, Rabinowitz J. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020;31(4):809–821.e6. PMCID: PMC7397714 Reference Link
1.Ron-Harel N, Ghergurovich J, Notarangelo G, LaFleur M, Tsubosaka Y, Sharpe A, Rabinowitz J, Haigis M. T Cell Activation Depends on Extracellular Alanine. Cell Rep. 2019;28(12):3011–3021.e4. PMCID: PMC6934407 Reference Link
1.Ron-Harel N, Notarangelo G, Ghergurovich J, Paulo J, Sage P, Santos D, Satterstrom K, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347–13352. PMCID: PMC6310842 Reference Link
1.Pavlova N, Hui S, Ghergurovich J, Fan J, Intlekofer A, White R, Rabinowitz J, Thompson C, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metab. 2018;27(2):428–438.e5. PMCID: PMC5803449 Reference Link
1.Ducker G, Ghergurovich J, Mainolfi N, Suri V, Jeong S, Li S, Friedman A, Manfredi M, Gitai Z, Kim H, Rabinowitz J. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114(43):11404–11409. PMCID: PMC5664509 Reference Link
1.Hui S, Ghergurovich J, Morscher R, Jang C, Teng X, Lu W, Esparza L, Reya T, Guo J, White E, Rabinowitz J. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115–118. PMCID: PMC5898814 Reference Link
1.Ron-Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, Dephoure N, Satterstrom K, Sheffer M, Spinelli J, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24(1):104–17. PMCID: PMC5330619 Reference Link
1.Ducker G, Chen L, Morscher R, Ghergurovich J, Esposito M, Teng X, Kang Y, Rabinowitz J. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016;23(6):1140–1153. PMCID: PMC4909566 Reference Link