Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419

Ghergurovich J, Lang J, Levin M, Briones N, Facista S, Mueller C, Cowan A, McBride M, Rodriguez E, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks W, Espina V, Von Hoff D, O’Shaughnessy J, Rabinowitz J. Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med. 2021;2(6):736–754. PMCID: PMC8248508

Zhang Y, Xu Y, Lu W, Ghergurovich J, Guo L, Blair I, Rabinowitz J, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94–109.e8. PMCID: PMC7846267

Ghergurovich J, Esposito M, Chen Z, Wang J, Bhatt V, Lan T, White E, Kang Y, Guo J, Rabinowitz J. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020;80(18):3820–3829. PMCID: PMC7501231

García-Cañaveras J, Lancho O, Ducker G, Ghergurovich J, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz J. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35(2):377–388. PMCID: PMC7647950

Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271

Yang L, Canaveras J, Chen Z, Wang L, Liang L, Jang C, Mayr J, Zhang Z, Ghergurovich J, Zhan L, Joshi S, Hu Z, McReynolds M, Su X, White E, Morscher R, Rabinowitz J. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020;31(4):809–821.e6. PMCID: PMC7397714

Ron-Harel N, Ghergurovich J, Notarangelo G, LaFleur M, Tsubosaka Y, Sharpe A, Rabinowitz J, Haigis M. T Cell Activation Depends on Extracellular Alanine. Cell Rep. 2019;28(12):3011–3021.e4. PMCID: PMC6934407

Ron-Harel N, Notarangelo G, Ghergurovich J, Paulo J, Sage P, Santos D, Satterstrom K, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347–13352. PMCID: PMC6310842

Pavlova N, Hui S, Ghergurovich J, Fan J, Intlekofer A, White R, Rabinowitz J, Thompson C, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metab. 2018;27(2):428–438.e5. PMCID: PMC5803449

Ducker G, Ghergurovich J, Mainolfi N, Suri V, Jeong S, Li S, Friedman A, Manfredi M, Gitai Z, Kim H, Rabinowitz J. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114(43):11404–11409. PMCID: PMC5664509

Hui S, Ghergurovich J, Morscher R, Jang C, Teng X, Lu W, Esparza L, Reya T, Guo J, White E, Rabinowitz J. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115–118. PMCID: PMC5898814

Ron-Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, Dephoure N, Satterstrom K, Sheffer M, Spinelli J, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24(1):104–17. PMCID: PMC5330619

Ducker G, Chen L, Morscher R, Ghergurovich J, Esposito M, Teng X, Kang Y, Rabinowitz J. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016;23(6):1140–1153. PMCID: PMC4909566