1.Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, García-Cañaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55(1):65–81.e9. PMCID: PMC8755618 Reference Link
1.García-Cañaveras J, Heo D, Trefely S, Leferovich J, Xu C, Philipson B, Ghassemi S, Milone M, Moon E, Snyder N, June C, Rabinowitz J, O’Connor R. CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells. 2021;10(9). PMCID: PMC8472053 Reference Link
1.Ringel A, Drijvers J, Baker G, Catozzi A, García-Cañaveras J, Gassaway B, Miller B, Juneja V, Nguyen T, Joshi S, Yao C-H, Yoon H, Sage P, LaFleur M, Trombley J, Jacobson C, Maliga Z, Gygi S, Sorger P, Rabinowitz J, Sharpe A, Haigis M. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848–1866.e26. PMCID: PMC8064125 Reference Link
1.Xu Y, Zhang Y, García-Cañaveras J, Guo L, Kan M, Yu S, Blair I, Rabinowitz J, Yang X. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020;369(6502):397–403. PMCID: PMC7939502 Reference Link
1.García-Cañaveras J, Lancho O, Ducker G, Ghergurovich J, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz J. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35(2):377–388. PMCID: PMC7647950 Reference Link
1.Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271 Reference Link
1.Hermans D, Gautam S, García-Cañaveras J, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin J-X, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers L, Rabinowitz J, Gattinoni L, Leonard W. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020;117(11):6047–6055. PMCID: PMC7084161 Reference Link
1.García-Cañaveras J, Chen L, Rabinowitz J. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019;79(13):3155–3162. PMCID: PMC6606343 Reference Link
