1.Tang J, Brynildsen M. Genome-wide mapping of fluoroquinolone-stabilized DNA gyrase cleavage sites displays drug specific effects that correlate with bacterial persistence. Nucleic Acids Res. 2023;51(3):1208–1228. PMCID: PMC9943676 Reference Link
1.Thokkadam A, Do T, Ran X, Brynildsen M, Yang Z, Link J. High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin. ACS Cent Sci. 2023;9(3):540–550. PMCID: PMC10037499 Reference Link
1.Chiu S, Hancock A, Schofner B, Sniezek K, Soto-Echevarria N, Leon G, Sivaloganathan D, Wan X, Brynildsen M. Causes of polymyxin treatment failure and new derivatives to fill the gap. J Antibiot (Tokyo). 2022;75(11):593–609. PMCID: 2048009 Reference Link
1.Lemma A, Soto-Echevarria N, Brynildsen M. Fluoroquinolone Persistence in Requires DNA Repair despite Differing between Starving Populations. Microorganisms. 2022;10(2). PMCID: PMC8877308 Reference Link
1.Wan X, Link J, Brynildsen M. Translational Fusion to Hmp Improves Heterologous Protein Expression. Microorganisms. 2022;10(2). PMCID: PMC8879370 Reference Link
1.Wan X, Brynildsen M. Robustness of nitric oxide detoxification to nitrogen starvation in Escherichia coli requires RelA. Free Radic Biol Med. 2021;176:286–297. PMID: 34624482 Reference Link
1.Murawski A, Rittenbach K, DeCoste C, Laevsky G, Brynildsen M. Counting Chromosomes in Individual Bacteria to Quantify Their Impacts on Persistence. Methods Mol Biol. 2021;2357:125–146. PMCID: 7136161 Reference Link
1.Adams R, Leon G, Miller N, Reyes S, Thantrong C, Thokkadam A, Lemma A, Sivaloganathan D, Wan X, Brynildsen M. Rifamycin antibiotics and the mechanisms of their failure. J Antibiot (Tokyo). 2021;74(11):786–798. PMCID: 4930915 Reference Link
1.Lemma A, Brynildsen M. Toxin Induction or Inhibition of Transcription or Translation Posttreatment Increases Persistence to Fluoroquinolones. mBio. 2021;12(4):e0198321. PMCID: PMC8406316 Reference Link
1.Murawski A, Brynildsen M. Ploidy is an important determinant of fluoroquinolone persister survival. Curr Biol. 2021;31(10):2039–2050.e7. PMCID: PMC8183807 Reference Link
1.Sivaloganathan D, Brynildsen M. Pseudomonas aeruginosa prioritizes detoxification of hydrogen peroxide over nitric oxide. BMC Res Notes. 2021;14(1):120. PMCID: PMC7995768 Reference Link
1.Sivaloganathan D, Brynildsen M. Phagosome-Bacteria Interactions from the Bottom Up. Annu Rev Chem Biomol Eng. 2021;12:309–331. PMID: 33781082 Reference Link
1.Aedo S, Tang J, Brynildsen M. Metabolites Potentiate Nitrofurans in Nongrowing Escherichia coli. Antimicrob Agents Chemother. 2021;65(3). PMCID: PMC8092534 Reference Link
1.Chou W, Vaikunthan M, Schröder H, Link J, Kim H, Brynildsen M. Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide. Front Bioeng Biotechnol. 2020;8:1001. PMCID: PMC7477088 Reference Link
1.Sivaloganathan D, Brynildsen M. Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide. Front Physiol. 2020;11:330. PMCID: PMC7181900 Reference Link
1.Sivaloganathan D, Wan X, Brynildsen M. Quantifying Nitric Oxide Flux Distributions. Methods Mol Biol. 2020;2088:161–188. PMID: 31893374 Reference Link
1.Adolfsen K, Chou W, Brynildsen M. Transcriptional Regulation Contributes to Prioritized Detoxification of Hydrogen Peroxide over Nitric Oxide. J Bacteriol. 2019;201(14). PMCID: PMC6597392 Reference Link
1.Aedo S, Orman M, Brynildsen M. Stationary phase persister formation in Escherichia coli can be suppressed by piperacillin and PBP3 inhibition. BMC Microbiol. 2019;19(1):140. PMCID: PMC6591824 Reference Link
1.Balaban N, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson D, Brynildsen M, Bumann D, Camilli A, Collins J, Dehio C, Fortune S, Ghigo J-M, Hardt W-D, Harms A, Heinemann M, Hung D, Jenal U, Levin B, Michiels J, Storz G, Tan M-W, Tenson T, Van Melderen L, Zinkernagel A. Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019;17(7):441–448. PMCID: PMC7136161 Reference Link
1.Balaban N, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson D, Brynildsen M, Bumann D, Camilli A, Collins J, Dehio C, Fortune S, Ghigo J-M, Hardt W-D, Harms A, Heinemann M, Hung D, Jenal U, Levin B, Michiels J, Storz G, Tan M-W, Tenson T, Van Melderen L, Zinkernagel A. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019;17(7):460. PMCID: PMC7609342 Reference Link
1.Aedo S, Ma H, Brynildsen M. Checks and Balances with Use of the Keio Collection for Phenotype Testing. Methods Mol Biol. 2019;1927:125–138. PMID: 30788789 Reference Link
1.Barrett T, Mok W, Murawski A, Brynildsen M. Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic. Nat Commun. 2019;10(1):1177. PMCID: PMC6414640 Reference Link
1.Chou W, Brynildsen M. Loss of DksA leads to multi-faceted impairment of nitric oxide detoxification by Escherichia coli. Free Radic Biol Med. 2019;130:288–296. PMID: 30366060 Reference Link
1.Gowers G-O, Robinson J, Brynildsen M. Corrigendum to "Starved Escherichia coli preserve reducing power under nitric oxide stress" Biochemical and Biophysical Research Communications, Volume 476, Issue 115, July 2016, Pages 29-34. Biochem Biophys Res Commun. 2018;505(2):631. PMID: 30224055 Reference Link
1.Brynildsen M. Nitric Oxide Stress as a Metabolic Flux. Adv Microb Physiol. 2018;73:63–76. PMID: 30262110 Reference Link
1.Mok W, Brynildsen M. Timing of DNA damage responses impacts persistence to fluoroquinolones. Proc Natl Acad Sci U S A. 2018;115(27):E6301-E6309. PMCID: PMC6142227 Reference Link
1.Aedo S, Gelderman G, Brynildsen M. Tackling host-circuit give and take. Nat Microbiol. 2017;2(12):1584–1585. PMID: 29176699 Reference Link
1.Barrett T, Mok W, Brynildsen M. Biased inheritance protects older bacteria from harm. Science. 2017;356(6335):247–248. PMID: 28428383 Reference Link
1.Sacco S, Adolfsen K, Brynildsen M. An integrated network analysis identifies how ArcAB enables metabolic oscillations in the nitric oxide detoxification network of Escherichia coli. Biotechnol J. 2017;12(8). PMID: 28449226 Reference Link
1.Robinson J, Jaslove J, Murawski A, Fazen C, Brynildsen M. An integrated network analysis reveals that nitric oxide reductase prevents metabolic cycling of nitric oxide by Pseudomonas aeruginosa. Metab Eng. 2017;41:67–81. PMID: 28363762 Reference Link
1.Mok W, Brynildsen M. An Orphan Riboswitch Unveils Guanidine Regulation in Bacteria. Mol Cell. 2017;65(2):205–206. PMID: 28107646 Reference Link
1.Adolfsen K, Brynildsen M. A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli. PLoS Comput Biol. 2015;11(11):e1004562. PMCID: PMC4636272 Reference Link
1.Orman M, Brynildsen M. Inhibition of stationary phase respiration impairs persister formation in E. coli. Nat Commun. 2015;6:7983. PMCID: PMC4530465 Reference Link
1.Amato S, Brynildsen M. Persister Heterogeneity Arising from a Single Metabolic Stress. Curr Biol. 2015;25(16):2090–8. PMID: 26255847 Reference Link
1.Völzing K, Brynildsen M. Stationary-Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery. mBio. 2015;6(5):e00731–15. PMCID: PMC4556807 Reference Link
1.Henry T, Brynildsen M. Development of Persister-FACSeq: a method to massively parallelize quantification of persister physiology and its heterogeneity. Sci Rep. 2016;6:25100. PMCID: PMC4855238 Reference Link
1.Gowers G-O, Robinson J, Brynildsen M. Starved Escherichia coli preserve reducing power under nitric oxide stress. Biochem Biophys Res Commun. 2016;476(1):29–34. PMID: 27207837 Reference Link
1.Orman M, Mok W, Brynildsen M. Aminoglycoside-enabled elucidation of bacterial persister metabolism. Curr Protoc Microbiol. 2015;36:17.9.1–17.9.14. PMCID: PMC4380151 Reference Link
1.Robinson J, Brynildsen M. An ensemble-guided approach identifies ClpP as a major regulator of transcript levels in nitric oxide-stressed Escherichia coli. Metab Eng. 2015;31:22–34. PMID: 26112956 Reference Link
1.Orman M, Henry T, DeCoste C, Brynildsen M. Analyzing Persister Physiology with Fluorescence-Activated Cell Sorting. Methods Mol Biol. 2016;1333:83–100. PMCID: PMC4908830 Reference Link
1.Mok W, Park J, Rabinowitz J, Brynildsen M. RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. mBio. 2015;6(6):e01588–15. PMCID: PMC4659464 Reference Link
1.Sandvik E, Fazen C, Henry T, Mok W, Brynildsen M. Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters. Pharmaceuticals (Basel). 2015;8(4):778–92. PMCID: PMC4695809 Reference Link
1.Orman M, Brynildsen M. Persister formation in Escherichia coli can be inhibited by treatment with nitric oxide. Free Radic Biol Med. 2016;93:145–54. PMCID: PMC4898466 Reference Link
1.Robinson J, Brynildsen M. Discovery and dissection of metabolic oscillations in the microaerobic nitric oxide response network of Escherichia coli. Proc Natl Acad Sci U S A. 2016;113(12):E1757–66. PMCID: PMC4812703 Reference Link
1.Henry T, Brynildsen M. Quantifying Current Events Identifies a Novel Endurance Regulator. Trends Microbiol. 2016;24(5):324–326. PMCID: PMC4841710 Reference Link
