Conserved regulators of cognitive aging: From worms to humans.

TitleConserved regulators of cognitive aging: From worms to humans.
Publication TypeJournal Article
Year of Publication2017
AuthorsArey, RN, Murphy, CT
JournalBehav Brain Res
Volume322
IssuePt B
Pagination299-310
Date Published2017 03 30
ISSN1872-7549
KeywordsAnimals, Caenorhabditis elegans, Cognitive Aging, Humans, Models, Animal
Abstract

<p>Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging.</p>

DOI10.1016/j.bbr.2016.06.035
Alternate JournalBehav. Brain Res.
PubMed ID27329151
PubMed Central IDPMC5164975
Grant ListF32 AG046106 / AG / NIA NIH HHS / United States
R01 AG034446 / AG / NIA NIH HHS / United States