Title | Computational models of airway branching morphogenesis. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Varner, VD, Nelson, CM |
Journal | Semin Cell Dev Biol |
Volume | 67 |
Pagination | 170-176 |
Date Published | 2017 07 |
ISSN | 1096-3634 |
Keywords | Animals, Biomechanical Phenomena, Cell Culture Techniques, Computer Simulation, Embryo, Mammalian, Epithelial Cells, Fibroblast Growth Factor 10, Gene Expression Regulation, Humans, Lung, Mechanotransduction, Cellular, Mice, Models, Anatomic, Models, Biological, Morphogenesis, Stress, Mechanical |
Abstract | <p>The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches - geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling - and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.</p> |
DOI | 10.1016/j.semcdb.2016.06.003 |
Alternate Journal | Semin Cell Dev Biol |
PubMed ID | 27269374 |
PubMed Central ID | PMC5136345 |
Grant List | R01 GM083997 / GM / NIGMS NIH HHS / United States R01 HL120142 / HL / NHLBI NIH HHS / United States R21 HL110335 / HL / NHLBI NIH HHS / United States R21 HL118532 / HL / NHLBI NIH HHS / United States |