Computational models of airway branching morphogenesis.

TitleComputational models of airway branching morphogenesis.
Publication TypeJournal Article
Year of Publication2016
AuthorsVarner, VD, Nelson, CM
JournalSemin Cell Dev Biol
Date Published2016 Jun 3
ISSN1096-3634
Abstract

The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches - geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling - and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.

DOI10.1016/j.semcdb.2016.06.003
Alternate JournalSemin. Cell Dev. Biol.
PubMed ID27269374
Grant ListR01 HL120142 / HL / NHLBI NIH HHS / United States
R21 HL110335 / HL / NHLBI NIH HHS / United States
R21 HL118532 / HL / NHLBI NIH HHS / United States