Computational models of airway branching morphogenesis.

TitleComputational models of airway branching morphogenesis.
Publication TypeJournal Article
Year of Publication2017
AuthorsVarner, VD, Nelson, CM
JournalSemin Cell Dev Biol
Date Published2017 Jul
KeywordsAnimals, Biomechanical Phenomena, Cell Culture Techniques, Computer Simulation, Embryo, Mammalian, Epithelial Cells, Fibroblast Growth Factor 10, Gene Expression Regulation, Humans, Lung, Mechanotransduction, Cellular, Mice, Models, Anatomic, Models, Biological, Morphogenesis, Stress, Mechanical

<p>The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches - geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling - and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.</p>

Alternate JournalSemin Cell Dev Biol
PubMed ID27269374
PubMed Central IDPMC5136345
Grant ListR01 GM083997 / GM / NIGMS NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States
R21 HL110335 / HL / NHLBI NIH HHS / United States
R21 HL118532 / HL / NHLBI NIH HHS / United States