| Title | Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Gibney, PA, Schieler, A, Chen, JC, Bacha-Hummel, JM, Botstein, M, Volpe, M, Silverman, SJ, Xu, Y, Bennett, BD, Rabinowitz, JD, Botstein, D |
| Journal | Mol Biol Cell |
| Volume | 29 |
| Issue | 8 |
| Pagination | 897-910 |
| Date Published | 2018 04 15 |
| ISSN | 1939-4586 |
| Keywords | Culture Media, Fructosephosphates, Galactosephosphates, Gene Expression Regulation, Fungal, Genes, Fungal, Genes, Suppressor, Mutation, Saccharomyces cerevisiae |
| Abstract | <p>Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.</p> |
| DOI | 10.1091/mbc.E17-11-0666 |
| Alternate Journal | Mol Biol Cell |
| PubMed ID | 29444955 |
| PubMed Central ID | PMC5896929 |
| Grant List | F32 GM097852 / GM / NIGMS NIH HHS / United States P50 GM071508 / GM / NIGMS NIH HHS / United States R01 GM046406 / GM / NIGMS NIH HHS / United States R37 GM046406 / GM / NIGMS NIH HHS / United States |
