Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

TitleCommon and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.
Publication TypeJournal Article
Year of Publication2018
AuthorsGibney, PA, Schieler, A, Chen, JC, Bacha-Hummel, JM, Botstein, M, Volpe, M, Silverman, SJ, Xu, Y, Bennett, BD, Rabinowitz, JD, Botstein, D
JournalMol Biol Cell
Volume29
Issue8
Pagination897-910
Date Published2018 04 15
ISSN1939-4586
KeywordsCulture Media, Fructosephosphates, Galactosephosphates, Gene Expression Regulation, Fungal, Genes, Fungal, Genes, Suppressor, Mutation, Saccharomyces cerevisiae
Abstract

<p>Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.</p>

DOI10.1091/mbc.E17-11-0666
Alternate JournalMol Biol Cell
PubMed ID29444955
PubMed Central IDPMC5896929
Grant ListF32 GM097852 / GM / NIGMS NIH HHS / United States
P50 GM071508 / GM / NIGMS NIH HHS / United States
R01 GM046406 / GM / NIGMS NIH HHS / United States
R37 GM046406 / GM / NIGMS NIH HHS / United States