Collective Behavior of Place and Non-place Neurons in the Hippocampal Network.

TitleCollective Behavior of Place and Non-place Neurons in the Hippocampal Network.
Publication TypeJournal Article
Year of Publication2017
AuthorsMeshulam, L, Gauthier, JL, Brody, CD, Tank, DW, Bialek, W
JournalNeuron
Volume96
Issue5
Pagination1178-1191.e4
Date Published2017 Dec 06
ISSN1097-4199
KeywordsAction Potentials, Algorithms, Animals, CA1 Region, Hippocampal, Entropy, Hippocampus, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Nerve Net, Neurons, Photic Stimulation, Space Perception, User-Computer Interface
Abstract

<p>Discussions of the hippocampus often focus on place cells, but many neurons are not place cells in any given environment. Here we describe the collective activity in such mixed populations, treating place and non-place cells on the same footing. We start with optical imaging experiments on CA1 in mice as they run along a virtual linear track and use maximum entropy methods to approximate the distribution of patterns of activity in the population, matching the correlations between pairs of cells but otherwise assuming as little structure as possible. We find that these simple models accurately predict the activity of each neuron from the state of all the other neurons in the network, regardless of how well that neuron codes for position. Our results suggest that understanding the neural activity may require not only knowledge of the external variables modulating it but also of the internal network state.</p>

DOI10.1016/j.neuron.2017.10.027
Alternate JournalNeuron
PubMed ID29154129
PubMed Central IDPMC5720931
Grant List / / Howard Hughes Medical Institute / United States