The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy.

Publication Year
2020

Type

Journal Article
Abstract

Bactobolin is a hybrid natural product with potent cytotoxic activity. Its production from was reported as part of a collaboration between the Greenberg and Clardy laboratories in 2010. The collaboration sparked a series of studies leading to the discovery of new analogues and associated structure-activity relationships, the identification of the bactobolin biosynthetic gene cluster and assembly of its unusual amino acid building block, the molecular target of and resistance to the antibiotic, and finally an X-ray crystal structure of the ribosome-bactobolin complex. Herein, we review the collaborations that led to our current understanding of the chemistry and biology of bactobolin.

Journal
J Nat Prod
Volume
83
Issue
3
Pages
738-743
Date Published
2020 Mar 27
ISSN Number
1520-6025
Alternate Journal
J Nat Prod
PMCID
PMC8118907
PMID
32105069