The cerebellum, sensitive periods, and autism.

TitleThe cerebellum, sensitive periods, and autism.
Publication TypeJournal Article
Year of Publication2014
AuthorsWang, SS-H, Kloth, AD, Badura, A
JournalNeuron
Volume83
Issue3
Pagination518-32
Date Published2014 Aug 06
ISSN1097-4199
KeywordsAutistic Disorder, Brain Mapping, Cerebellum, Cognition, Gene Expression, Humans, Learning, Male
Abstract

<p>Cerebellar research has focused principally on adult motor function. However, the cerebellum also maintains abundant connections with nonmotor brain regions throughout postnatal life. Here we review evidence that the cerebellum may guide the maturation of remote nonmotor neural circuitry and influence cognitive development, with a focus on its relationship with autism. Specific cerebellar zones influence neocortical substrates for social interaction, and we propose that sensitive-period disruption of such internal brain communication can account for autism's key features.</p>

DOI10.1016/j.neuron.2014.07.016
Alternate JournalNeuron
PubMed ID25102558
PubMed Central IDPMC4135479
Grant ListF31 MH098651 / MH / NIMH NIH HHS / United States
R01 NS045193 / NS / NINDS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States