Cerebellar involvement in an evidence-accumulation decision-making task.

TitleCerebellar involvement in an evidence-accumulation decision-making task.
Publication TypeJournal Article
Year of Publication2018
AuthorsDeverett, B, Koay, SAnn, Oostland, M, Wang, SS-H
JournalElife
Volume7
Date Published2018 Aug 13
ISSN2050-084X
Abstract

To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials. Using two-photon fluorescence imaging of calcium, we found that Purkinje cell somatic activity contained choice/evidence-related information. Decision errors were represented by dendritic calcium spikes, which in other contexts are known to drive cerebellar plasticity. We propose that cerebellar circuitry may contribute to computations that support accurate performance in this perceptual decision-making task.

DOI10.7554/eLife.36781
Alternate JournalElife
PubMed ID30102151
Grant ListMH115577 / / National Institute of Mental Health /
NS045193 / / National Institute of Neurological Disorders and Stroke /
NS090541 / / National Institute of Neurological Disorders and Stroke /
NS104648 / / National Institute of Neurological Disorders and Stroke /
MH115750 / / National Institute of Mental Health /