Title | Cerebellar involvement in an evidence-accumulation decision-making task. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Deverett, B, Koay, SAnn, Oostland, M, Wang, SS-H |
Journal | Elife |
Volume | 7 |
Date Published | 2018 08 13 |
ISSN | 2050-084X |
Keywords | Action Potentials, Animals, Behavior, Animal, Calcium Signaling, Cerebellum, Decision Making, Female, Male, Mice, Neurons, Perception |
Abstract | <p>To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials. Using two-photon fluorescence imaging of calcium, we found that Purkinje cell somatic activity contained choice/evidence-related information. Decision errors were represented by dendritic calcium spikes, which in other contexts are known to drive cerebellar plasticity. We propose that cerebellar circuitry may contribute to computations that support accurate performance in this perceptual decision-making task.</p> |
DOI | 10.7554/eLife.36781 |
Alternate Journal | Elife |
PubMed ID | 30102151 |
PubMed Central ID | PMC6105309 |
Grant List | MH115577 / MH / NIMH NIH HHS / United States R01 MH115750 / MH / NIMH NIH HHS / United States U19 NS104648 / NS / NINDS NIH HHS / United States NS045193 / NS / NINDS NIH HHS / United States NS090541 / NS / NINDS NIH HHS / United States R01 NS045193 / NS / NINDS NIH HHS / United States U01 NS090541 / NS / NINDS NIH HHS / United States MH115750 / MH / NIMH NIH HHS / United States F30 MH115577 / MH / NIMH NIH HHS / United States NS104648 / NS / NINDS NIH HHS / United States |