Cerebellar involvement in an evidence-accumulation decision-making task.

TitleCerebellar involvement in an evidence-accumulation decision-making task.
Publication TypeJournal Article
Year of Publication2018
AuthorsDeverett, B, Koay, SAnn, Oostland, M, Wang, SS-H
JournalElife
Volume7
Date Published2018 08 13
ISSN2050-084X
KeywordsAction Potentials, Animals, Behavior, Animal, Calcium Signaling, Cerebellum, Decision Making, Female, Male, Mice, Neurons, Perception
Abstract

<p>To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials. Using two-photon fluorescence imaging of calcium, we found that Purkinje cell somatic activity contained choice/evidence-related information. Decision errors were represented by dendritic calcium spikes, which in other contexts are known to drive cerebellar plasticity. We propose that cerebellar circuitry may contribute to computations that support accurate performance in this perceptual decision-making task.</p>

DOI10.7554/eLife.36781
Alternate JournalElife
PubMed ID30102151
PubMed Central IDPMC6105309
Grant ListMH115577 / MH / NIMH NIH HHS / United States
R01 MH115750 / MH / NIMH NIH HHS / United States
U19 NS104648 / NS / NINDS NIH HHS / United States
NS045193 / NS / NINDS NIH HHS / United States
NS090541 / NS / NINDS NIH HHS / United States
R01 NS045193 / NS / NINDS NIH HHS / United States
U01 NS090541 / NS / NINDS NIH HHS / United States
MH115750 / MH / NIMH NIH HHS / United States
F30 MH115577 / MH / NIMH NIH HHS / United States
NS104648 / NS / NINDS NIH HHS / United States