Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

TitleCerebellar granule cells acquire a widespread predictive feedback signal during motor learning.
Publication TypeJournal Article
Year of Publication2017
AuthorsGiovannucci, A, Badura, A, Deverett, B, Najafi, F, Pereira, TD, Gao, Z, Ozden, I, Kloth, AD, Pnevmatikakis, E, Paninski, L, De Zeeuw, CI, Medina, JF, Wang, SS-H
JournalNat Neurosci
Volume20
Issue5
Pagination727-734
Date Published2017 May
ISSN1546-1726
KeywordsAnimals, Anticipation, Psychological, Cerebellum, Conditioning, Classical, Feedback, Learning, Male, Mice, Mice, Transgenic, Neurons
Abstract

<p>Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track neural activity over multiple days of cerebellum-dependent eyeblink conditioning in mice, that granule cell populations acquire a dense representation of the anticipatory eyelid movement. Initially, granule cells responded to neutral visual and somatosensory stimuli as well as periorbital airpuffs used for training. As learning progressed, two-thirds of monitored granule cells acquired a conditional response whose timing matched or preceded the learned eyelid movements. Granule cell activity covaried trial by trial to form a redundant code. Many granule cells were also active during movements of nearby body structures. Thus, a predictive signal about the upcoming movement is widely available at the input stage of the cerebellar cortex, as required by forward models of cerebellar control.</p>

DOI10.1038/nn.4531
Alternate JournalNat. Neurosci.
PubMed ID28319608
PubMed Central IDPMC5704905
Grant ListR01 MH093727 / MH / NIMH NIH HHS / United States
R01 EB022913 / EB / NIBIB NIH HHS / United States
RF1 MH114269 / MH / NIMH NIH HHS / United States
R21 AA025572 / AA / NIAAA NIH HHS / United States
R01 NS045193 / NS / NINDS NIH HHS / United States