Cerebellar disruption impairs working memory during evidence accumulation.

TitleCerebellar disruption impairs working memory during evidence accumulation.
Publication TypeJournal Article
Year of Publication2019
AuthorsDeverett, B, Kislin, M, Tank, DW, Wang, SS-H
JournalNat Commun
Volume10
Issue1
Pagination3128
Date Published2019 07 16
ISSN2041-1723
KeywordsAnimals, Behavior, Animal, Cerebellum, Craniotomy, Decision Making, Female, Male, Memory, Short-Term, Mice, Models, Animal, Optogenetics, Photic Stimulation, Purkinje Cells
Abstract

To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.

DOI10.1038/s41467-019-11050-x
Alternate JournalNat Commun
PubMed ID31311934
PubMed Central IDPMC6635393
Grant ListR01 MH115750 / MH / NIMH NIH HHS / United States
U19 NS104648 / NS / NINDS NIH HHS / United States
R01 NS045193 / NS / NINDS NIH HHS / United States
F30 MH115577 / MH / NIMH NIH HHS / United States