Title | Cerebellar disruption impairs working memory during evidence accumulation. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Deverett, B, Kislin, M, Tank, DW, Wang, SS-H |
Journal | Nat Commun |
Volume | 10 |
Issue | 1 |
Pagination | 3128 |
Date Published | 2019 07 16 |
ISSN | 2041-1723 |
Keywords | Animals, Behavior, Animal, Cerebellum, Craniotomy, Decision Making, Female, Male, Memory, Short-Term, Mice, Models, Animal, Optogenetics, Photic Stimulation, Purkinje Cells |
Abstract | <p>To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.</p> |
DOI | 10.1038/s41467-019-11050-x |
Alternate Journal | Nat Commun |
PubMed ID | 31311934 |
PubMed Central ID | PMC6635393 |
Grant List | R01 MH115750 / MH / NIMH NIH HHS / United States U19 NS104648 / NS / NINDS NIH HHS / United States R01 NS045193 / NS / NINDS NIH HHS / United States F30 MH115577 / MH / NIMH NIH HHS / United States |