Cellular plasticity in bone metastasis. Author Cao Fang, Yibin Kang Publication Year 2022 Type Journal Article Abstract Metastasis is responsible for a large majority of death from malignant solid tumors. Bone is one of the most frequently affected organs in cancer metastasis, especially in breast and prostate cancer. Development of bone metastasis requires cancer cells to successfully complete a number of challenging steps, including local invasion and intravasation, survival in circulation, extravasation and initial seeding, and finally, formation of metastatic colonies after a period of dormancy or indolent growth. During this process, cancer cells often undergo a series of cellular and molecular changes to gain cellular plasticity that helps them adapt to various environments they encounter along the journey of metastasis. Understanding the mechanisms behind cellular plasticity and adaptation during the formation of bone metastasis is crucial for the development of novel therapies. Keywords Humans, Male, Bone Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms, Cell Plasticity Journal Bone Volume 158 Pages 115693 Date Published 2022 May ISSN Number 1873-2763 DOI 10.1016/j.bone.2020.115693 Alternate Journal Bone PMCID PMC8046848 PMID 33069922 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML