Cellular plasticity in bone metastasis.

Publication Year
2022

Type

Journal Article
Abstract

Metastasis is responsible for a large majority of death from malignant solid tumors. Bone is one of the most frequently affected organs in cancer metastasis, especially in breast and prostate cancer. Development of bone metastasis requires cancer cells to successfully complete a number of challenging steps, including local invasion and intravasation, survival in circulation, extravasation and initial seeding, and finally, formation of metastatic colonies after a period of dormancy or indolent growth. During this process, cancer cells often undergo a series of cellular and molecular changes to gain cellular plasticity that helps them adapt to various environments they encounter along the journey of metastasis. Understanding the mechanisms behind cellular plasticity and adaptation during the formation of bone metastasis is crucial for the development of novel therapies.

Journal
Bone
Volume
158
Pages
115693
Date Published
2022 May
ISSN Number
1873-2763
Alternate Journal
Bone
PMCID
PMC8046848
PMID
33069922