Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes. Author Md Ali, Kerwyn Huang, Ned Wingreen, Ranjan Mukhopadhyay Publication Year 2019 Type Journal Article Abstract We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization. Journal Phys Rev E Volume 99 Issue 1-1 Pages 012401 Date Published 2019 Jan ISSN Number 2470-0053 DOI 10.1103/PhysRevE.99.012401 Alternate Journal Phys Rev E PMCID PMC6553634 PMID 30780246 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML