Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.

TitleCell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.
Publication TypeJournal Article
Year of Publication2019
AuthorsAli, MZulfikar, Huang, KCasey, Wingreen, NS, Mukhopadhyay, R
JournalPhys Rev E
Volume99
Issue1-1
Pagination012401
Date Published2019 Jan
ISSN2470-0053
Abstract

We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.

DOI10.1103/PhysRevE.99.012401
Alternate JournalPhys Rev E
PubMed ID30780246
Grant ListR01 GM082938 / GM / NIGMS NIH HHS / United States