The cell biology of planar cell polarity.

Publication Year
2014

Type

Journal Article
Abstract

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.

Journal
J Cell Biol
Volume
207
Issue
2
Pages
171-9
Date Published
2014 Oct 27
ISSN Number
1540-8140
Alternate Journal
J Cell Biol
PMCID
PMC4210441
PMID
25349257