Causal contribution and dynamical encoding in the striatum during evidence accumulation.

TitleCausal contribution and dynamical encoding in the striatum during evidence accumulation.
Publication TypeJournal Article
Year of Publication2018
AuthorsYartsev, MM, Hanks, TD, Yoon, AMisun, Brody, CD
JournalElife
Volume7
Date Published2018 08 24
ISSN2050-084X
KeywordsAction Potentials, Animals, Behavior, Animal, Models, Neurological, Neostriatum, Neurons, Optogenetics, Rats, Sensation, Task Performance and Analysis
Abstract

<p>A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.</p>

DOI10.7554/eLife.34929
Alternate JournalElife
PubMed ID30141773
PubMed Central IDPMC6147735
Grant ListR01 MH108358 / MH / NIMH NIH HHS / United States
R01MH108358 / NH / NIH HHS / United States
Starr Fellowship / / Starr Foundation / International
F32MH098572 / NH / NIH HHS / United States