Capillary forces generated by biomolecular condensates.

TitleCapillary forces generated by biomolecular condensates.
Publication TypeJournal Article
Year of Publication2022
AuthorsGouveia, B, Kim, Y, Shaevitz, JW, Petry, S, Stone, HA, Brangwynne, CP
JournalNature
Volume609
Issue7926
Pagination255-264
Date Published2022 Sep
ISSN1476-4687
KeywordsBiomolecular Condensates, Cell Biology, Phase Transition
Abstract

<p>Liquid-liquid phase separation and related phase transitions have emerged as generic mechanisms in living cells for the formation of membraneless compartments or biomolecular condensates. The surface between two immiscible phases has an interfacial tension, generating capillary forces that can perform work on the surrounding environment. Here we present the physical principles of capillarity, including examples of how capillary forces structure multiphase condensates and remodel biological substrates. As with other mechanisms of intracellular force generation, for example, molecular motors, capillary forces can influence biological processes. Identifying the biomolecular determinants of condensate capillarity represents an exciting frontier, bridging soft matter physics and cell biology.</p>

DOI10.1038/s41586-022-05138-6
Alternate JournalNature
PubMed ID36071192
PubMed Central ID7434221
Grant List / HHMI / Howard Hughes Medical Institute / United States