The bright frontiers of microbial metabolic optogenetics.

TitleThe bright frontiers of microbial metabolic optogenetics.
Publication TypeJournal Article
Year of Publication2022
AuthorsWegner, SA, Barocio-Galindo, RM, Avalos, JL
JournalCurr Opin Chem Biol
Volume71
Pagination102207
Date Published2022 Sep 11
ISSN1879-0402
Abstract

<p>In recent years, light-responsive systems from the field of optogenetics have been applied to several areas of metabolic engineering with remarkable success. By taking advantage of light's high tunability, reversibility, and orthogonality to host endogenous processes, optogenetic systems have enabled unprecedented dynamical controls of microbial fermentations for chemical production, metabolic flux analysis, and population compositions in co-cultures. In this article, we share our opinions on the current state of this new field of metabolic optogenetics.We make the case that it will continue to impact metabolic engineering in increasingly new directions, with the potential to challenge existing paradigms for metabolic pathway and strain optimization as well as bioreactor operation.</p>

DOI10.1016/j.cbpa.2022.102207
Alternate JournalCurr Opin Chem Biol
PubMed ID36103753