| Title | Boron binding with the quorum sensing signal AI-2 and analogues. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Semmelhack, MF, Campagna, SR, Hwa, C, Federle, MJ, Bassler, BL |
| Journal | Org Lett |
| Volume | 6 |
| Issue | 15 |
| Pagination | 2635-7 |
| Date Published | 2004 Jul 22 |
| ISSN | 1523-7060 |
| Keywords | Boron, Magnetic Resonance Spectroscopy, Molecular Structure, Pentanes, Vibrio |
| Abstract | <p>[reaction: see text] The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi AI-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi AI-2 from the biosynthetic product.</p> |
| DOI | 10.1021/ol048976u |
| Alternate Journal | Org Lett |
| PubMed ID | 15255709 |
| Grant List | AI054442 / AI / NIAID NIH HHS / United States |
