Boron binding with the quorum sensing signal AI-2 and analogues.

TitleBoron binding with the quorum sensing signal AI-2 and analogues.
Publication TypeJournal Article
Year of Publication2004
AuthorsSemmelhack, MF, Campagna, SR, Hwa, C, Federle, MJ, Bassler, BL
JournalOrg Lett
Volume6
Issue15
Pagination2635-7
Date Published2004 Jul 22
ISSN1523-7060
KeywordsBoron, Magnetic Resonance Spectroscopy, Molecular Structure, Pentanes, Vibrio
Abstract

<p>[reaction: see text] The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi AI-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi AI-2 from the biosynthetic product.</p>

DOI10.1021/ol048976u
Alternate JournalOrg. Lett.
PubMed ID15255709
Grant ListAI054442 / AI / NIAID NIH HHS / United States