Border Control: Regulating LPS Biogenesis.

TitleBorder Control: Regulating LPS Biogenesis.
Publication TypeJournal Article
Year of Publication2021
AuthorsGuest, RL, Rutherford, ST, Silhavy, TJ
JournalTrends Microbiol
Volume29
Issue4
Pagination334-345
Date Published2021 Apr
ISSN1878-4380
Abstract

<p>The outer membrane (OM) is a defining feature of Gram-negative bacteria that serves as a permeability barrier and provides rigidity to the cell. Critical to OM function is establishing and maintaining an asymmetrical bilayer structure with phospholipids in the inner leaflet and the complex glycolipid lipopolysaccharide (LPS) in the outer leaflet. Cells ensure this asymmetry by regulating the biogenesis of lipid A, the conserved and essential anchor of LPS. Here we review the consequences of disrupting the regulatory components that control lipid A biogenesis, focusing on the rate-limiting step performed by LpxC. Dissection of these processes provides critical insights into bacterial physiology and potential new targets for antibiotics able to overcome rapidly spreading resistance mechanisms.</p>

DOI10.1016/j.tim.2020.09.008
Alternate JournalTrends Microbiol
PubMed ID33036869
PubMed Central IDPMC7969359
Grant ListR35 GM118024 / GM / NIGMS NIH HHS / United States