The Bony Side of Endothelial Cells in Prostate Cancer.

TitleThe Bony Side of Endothelial Cells in Prostate Cancer.
Publication TypeJournal Article
Year of Publication2017
AuthorsPeng, J, Kang, Y
JournalDev Cell
Volume41
Issue5
Pagination451-452
Date Published2017 06 05
ISSN1878-1551
KeywordsBone Neoplasms, Cell Line, Tumor, Endothelial Cells, Humans, Male, Osteoblasts, Prostatic Neoplasms
Abstract

<p>Prostate cancer bone metastases are primarily osteoblastic, but the source of bone-forming cells in these lesions remains poorly defined. In this issue of Developmental Cell, Lin et al. (2017) demonstrate that tumor-associated endothelial cells can give rise to osteoblasts in prostate cancer through endothelial-to-osteoblast (EC-to-OSB) conversion.</p>

DOI10.1016/j.devcel.2017.05.015
Alternate JournalDev. Cell
PubMed ID28586639