Bone marrow niches in the regulation of bone metastasis.

TitleBone marrow niches in the regulation of bone metastasis.
Publication TypeJournal Article
Year of Publication2021
AuthorsChen, F, Han, Y, Kang, Y
JournalBr J Cancer
Volume124
Issue12
Pagination1912-1920
Date Published2021 Jun
ISSN1532-1827
Abstract

<p>The bone marrow has been widely recognised to host a unique microenvironment that facilitates tumour colonisation. Bone metastasis frequently occurs in the late stages of malignant diseases such as breast, prostate and lung cancers. The biology of bone metastasis is determined by tumour-cell-intrinsic traits as well as their interaction with the microenvironment. The bone marrow is a dynamic organ in which various stages of haematopoiesis, osteogenesis, osteolysis and different kinds of immune response are precisely regulated. These different cellular components constitute specialised tissue microenvironments-niches-that play critical roles in controlling tumour cell colonisation, including initial seeding, dormancy and outgrowth. In this review, we will dissect the dynamic nature of the interactions between tumour cells and bone niches. By targeting certain steps of tumour progression and crosstalk with the bone niches, the development of potential therapeutic approaches for the clinical treatment of bone metastasis might be feasible.</p>

DOI10.1038/s41416-021-01329-6
Alternate JournalBr J Cancer
PubMed ID33758331
PubMed Central IDPMC8184962
Grant ListR01 CA141062 / CA / NCI NIH HHS / United States
R01CA141062 / / U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) /