Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

TitleBlowing Off Steam: Virus Inhibition of cGAS DNA Sensing.
Publication TypeJournal Article
Year of Publication2015
AuthorsDiner, BA, Cristea, IM
JournalCell Host Microbe
Volume18
Issue3
Pagination270-2
Date Published2015 Sep 09
ISSN1934-6069
KeywordsDNA, Viral, Herpesvirus 8, Human, Host-Pathogen Interactions, Humans, Immune Evasion, Nucleotidyltransferases, Viral Proteins
Abstract

<p>Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.</p>

DOI10.1016/j.chom.2015.08.012
Alternate JournalCell Host Microbe
PubMed ID26355212
PubMed Central IDPMC4920077
Grant ListR01 GM114141 / GM / NIGMS NIH HHS / United States
R21 AI102187 / AI / NIAID NIH HHS / United States