Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

TitleBlowing Off Steam: Virus Inhibition of cGAS DNA Sensing.
Publication TypeJournal Article
Year of Publication2015
AuthorsDiner, BA, Cristea, IM
JournalCell Host Microbe
Date Published2015 09 09
KeywordsDNA, Viral, Herpesvirus 8, Human, Host-Pathogen Interactions, Humans, Immune Evasion, Nucleotidyltransferases, Viral Proteins

Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.

Alternate JournalCell Host Microbe
PubMed ID26355212
PubMed Central IDPMC4920077
Grant ListR01 GM114141 / GM / NIGMS NIH HHS / United States
R21 AI102187 / AI / NIAID NIH HHS / United States