Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

Author
Benjamin Diner, Ileana Cristea
Publication Year
2015

Type

Journal Article
Abstract

Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.

Keywords
Humans, Viral Proteins, Host-Pathogen Interactions, DNA, Viral, Immune Evasion, Herpesvirus 8, Human, Nucleotidyltransferases
Journal
Cell Host Microbe
Volume
18
Issue
3
Pages
270-2
Date Published
2015 Sep 09
ISSN Number
1934-6069
DOI
10.1016/j.chom.2015.08.012
Alternate Journal
Cell Host Microbe
PMCID
PMC4920077
PMID
26355212