Biosynthesis: Leading the way to RiPPs.

TitleBiosynthesis: Leading the way to RiPPs.
Publication TypeJournal Article
Year of Publication2015
AuthorsA Link, J
JournalNat Chem Biol
Date Published2015 Aug
KeywordsAmino Acid Sequence, Bacteria, Bacteriocins, Biological Products, Conserved Sequence, Models, Molecular, Molecular Sequence Data, Peptides, PQQ Cofactor, Protein Processing, Post-Translational, Protein Sorting Signals, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Alignment

<p>Many peptide-based natural products require a leader peptide to reach their final modified form, but identifying general rules for leader peptide interactions have been stymied by the diversity of these molecules. Two papers reporting crystallographic and bioinformatic analysis of these systems now reveal a structurally-conserved domain that mediates leader peptide binding.</p>

Alternate JournalNat Chem Biol
PubMed ID26196773
PubMed Central IDPMC4794250
Grant ListR01 GM107036 / GM / NIGMS NIH HHS / United States