The Biology of Bone Metastasis.

TitleThe Biology of Bone Metastasis.
Publication TypeJournal Article
Year of Publication2018
AuthorsEsposito, M, Guise, T, Kang, Y
JournalCold Spring Harb Perspect Med
Volume8
Issue6
Date Published2018 06 01
ISSN2157-1422
KeywordsAnimals, Bone and Bones, Bone Neoplasms, Humans, Osteoblasts, Stem Cells, Tumor Microenvironment
Abstract

<p>Bone metastasis, or the development of secondary tumors within the bone of cancer patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone metastasis represents one of the most complex and intriguing of all oncogenic processes. This complexity derives from the intricately organized bone microenvironment in which the various stages of hematopoiesis, osteogenesis, and osteolysis are jointly regulated but spatially restricted. Disseminated tumor cells (DTCs) from various common malignancies such as breast, prostate, lung, and kidney cancers or myeloma are uniquely primed to subvert these endogenous bone stromal elements to grow into pathological osteolytic or osteoblastic lesions. This colonization process can be separated into three key steps: seeding, dormancy, and outgrowth. Targeting the processes of dormancy and initial outgrowth offers the most therapeutic promise. Here, we discuss the concepts of the bone metastasis niche, from controlling tumor-cell survival to growth into clinically detectable disease.</p>

DOI10.1101/cshperspect.a031252
Alternate JournalCold Spring Harb Perspect Med
PubMed ID29101110
PubMed Central IDPMC5980796
Grant ListU01 CA143057 / CA / NCI NIH HHS / United States
R01 CA212410 / CA / NCI NIH HHS / United States
R01 CA141062 / CA / NCI NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States
F31 CA192461 / CA / NCI NIH HHS / United States