I am grateful to have received the 2019 Women in Cell Biology Mid-Career Award from the American Society for Cell Biology. My lab has been studying aging and longevity regulation since 2005, but along the way we have had some surprises. These unexpected findings have morphed from detours to main directions, changing how I view biology. As I look back I've come to appreciate the importance and joy that can come from being open to these surprise interests and rigorously pursuing them.