Title | Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Poillet-Perez, L, Sharp, DW, Yang, Y, Laddha, SV, Ibrahim, M, Bommareddy, PK, Hu, ZSherrie, Vieth, J, Haas, M, Bosenberg, MW, Rabinowitz, JD, Cao, J, Guan, J-L, Ganesan, S, Chan, CS, Mehnert, JM, Lattime, EC, White, E |
Journal | Nat Cancer |
Volume | 1 |
Issue | 9 |
Pagination | 923-934 |
Date Published | 2020 Sep |
ISSN | 2662-1347 |
Keywords | Autophagy, Homeostasis, Humans, Immunity, Cellular, Mutation, Neoplasms |
Abstract | <p>Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy promotes tumor growth by providing essential tumor nutrients. Autophagy also regulates immune cell homeostasis and function and suppresses inflammation. Although host autophagy does not promote a T-cell anti-tumor immune response in tumors with low tumor mutational burden (TMB), whether this was the case in tumors with high TMB was not known. Here we show that autophagy, especially in the liver, promotes tumor immune tolerance by enabling regulatory T-cell function and limiting stimulator of interferon genes, T-cell response and interferon-γ, which enables growth of high-TMB tumors. We have designated this as hepatic autophagy immune tolerance. Autophagy thereby promotes tumor growth through both metabolic and immune mechanisms depending on mutational load and autophagy inhibition is an effective means to promote an antitumor T-cell response in high-TMB tumors.</p> |
DOI | 10.1038/s43018-020-00110-7 |
Alternate Journal | Nat Cancer |
PubMed ID | 34476408 |
PubMed Central ID | PMC8409526 |
Grant List | P30 CA072720 / CA / NCI NIH HHS / United States R01 CA193970 / CA / NCI NIH HHS / United States R01 CA243547 / CA / NCI NIH HHS / United States R01 CA163591 / CA / NCI NIH HHS / United States R01 CA211066 / CA / NCI NIH HHS / United States |