Asymmetry between Activators and Deactivators in Functional Protein Networks.

Publication Year
2020

Type

Journal Article
Abstract

Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive.

Journal
Sci Rep
Volume
10
Issue
1
Pages
10131
Date Published
2020 Jun 23
ISSN Number
2045-2322
Alternate Journal
Sci Rep
PMCID
PMC7311538
PMID
32576941