Asymmetry between Activators and Deactivators in Functional Protein Networks. Author Ammar Tareen, Ned Wingreen, Ranjan Mukhopadhyay Publication Year 2020 Type Journal Article Abstract Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive. Keywords Animals, Humans, Mutation, Phosphorylation, Protein Processing, Post-Translational, Algorithms, Proteins, Evolution, Molecular, Protein Interaction Maps, Protein Interaction Mapping Journal Sci Rep Volume 10 Issue 1 Pages 10131 Date Published 2020 Jun 23 ISSN Number 2045-2322 DOI 10.1038/s41598-020-66699-y Alternate Journal Sci Rep PMCID PMC7311538 PMID 32576941 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML