Asymmetry between Activators and Deactivators in Functional Protein Networks.

TitleAsymmetry between Activators and Deactivators in Functional Protein Networks.
Publication TypeJournal Article
Year of Publication2020
AuthorsTareen, A, Wingreen, NS, Mukhopadhyay, R
JournalSci Rep
Date Published2020 Jun 23
KeywordsAlgorithms, Animals, Evolution, Molecular, Humans, Mutation, Phosphorylation, Protein Interaction Mapping, Protein Interaction Maps, Protein Processing, Post-Translational, Proteins

<p>Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive.</p>

Alternate JournalSci Rep
PubMed ID32576941
PubMed Central IDPMC7311538