A antibiotic modulates human skin microbiota composition in hair follicles.

TitleA antibiotic modulates human skin microbiota composition in hair follicles.
Publication TypeJournal Article
Year of Publication2020
AuthorsClaesen, J, Spagnolo, JB, Ramos, SFlores, Kurita, KL, Byrd, AL, Aksenov, AA, Melnik, AV, Wong, WR, Wang, S, Hernandez, RD, Donia, MS, Dorrestein, PC, Kong, HH, Segre, JA, Linington, RG, Fischbach, MA, Lemon, KP
JournalSci Transl Med
Date Published2020 Nov 18
KeywordsAnti-Bacterial Agents, Hair Follicle, Humans, Microbiota, Propionibacterium acnes, Skin

<p>The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in (formerly ), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by species.</p>

Alternate JournalSci Transl Med
PubMed ID33208503
PubMed Central IDPMC8478231
Grant ListDP1 DK113598 / DK / NIDDK NIH HHS / United States
R01 AI101018 / AI / NIAID NIH HHS / United States
R01 DK110174 / DK / NIDDK NIH HHS / United States
U41 AT008718 / AT / NCCIH NIH HHS / United States