Title | A antibiotic modulates human skin microbiota composition in hair follicles. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Claesen, J, Spagnolo, JB, Ramos, SFlores, Kurita, KL, Byrd, AL, Aksenov, AA, Melnik, AV, Wong, WR, Wang, S, Hernandez, RD, Donia, MS, Dorrestein, PC, Kong, HH, Segre, JA, Linington, RG, Fischbach, MA, Lemon, KP |
Journal | Sci Transl Med |
Volume | 12 |
Issue | 570 |
Date Published | 2020 Nov 18 |
ISSN | 1946-6242 |
Keywords | Anti-Bacterial Agents, Hair Follicle, Humans, Microbiota, Propionibacterium acnes, Skin |
Abstract | <p>The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in (formerly ), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by species.</p> |
DOI | 10.1126/scitranslmed.aay5445 |
Alternate Journal | Sci Transl Med |
PubMed ID | 33208503 |
PubMed Central ID | PMC8478231 |
Grant List | DP1 DK113598 / DK / NIDDK NIH HHS / United States R01 AI101018 / AI / NIAID NIH HHS / United States R01 DK110174 / DK / NIDDK NIH HHS / United States U41 AT008718 / AT / NCCIH NIH HHS / United States |