All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models.

TitleAll models are wrong, but some are useful: Establishing standards for stem cell-based embryo models.
Publication TypeJournal Article
Year of Publication2021
AuthorsPosfai, E, Lanner, F, Mulas, C, Leitch, HG
JournalStem Cell Reports
Volume16
Issue5
Pagination1117-1141
Date Published2021 May 11
ISSN2213-6711
Abstract

<p>Detailed studies of the embryo allow an increasingly mechanistic understanding of development, which has proved of profound relevance to human disease. The last decade has seen in vitro cultured stem cell-based models of embryo development flourish, which provide an alternative to the embryo for accessible experimentation. However, the usefulness of any stem cell-based embryo model will be determined by how accurately it reflects in vivo embryonic development, and/or the extent to which it facilitates new discoveries. Stringent benchmarking of embryo models is thus an important consideration for this growing field. Here we provide an overview of means to evaluate both the properties of stem cells, the building blocks of most embryo models, as well as the usefulness of current and future in vitro embryo models.</p>

DOI10.1016/j.stemcr.2021.03.019
Alternate JournalStem Cell Reports
PubMed ID33979598
PubMed Central IDPMC8185978