Albusnodin: an acetylated lasso peptide from Streptomyces albus.

TitleAlbusnodin: an acetylated lasso peptide from Streptomyces albus.
Publication TypeJournal Article
Year of Publication2018
AuthorsZong, C, Cheung-Lee, WLing, Elashal, HE, Raj, M, A Link, J
JournalChem Commun (Camb)
Volume54
Issue11
Pagination1339-1342
Date Published2018 Feb 01
ISSN1364-548X
KeywordsAcetylation, Acetyltransferases, Amino Acid Sequence, Bacterial Proteins, Peptides, Cyclic, Protein Processing, Post-Translational, Streptomyces
Abstract

<p>We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.</p>

DOI10.1039/c7cc08620b
Alternate JournalChem. Commun. (Camb.)
PubMed ID29350227
PubMed Central IDPMC5835390
Grant ListR01 GM107036 / GM / NIGMS NIH HHS / United States