Albusnodin: an acetylated lasso peptide from Streptomyces albus.

TitleAlbusnodin: an acetylated lasso peptide from Streptomyces albus.
Publication TypeJournal Article
Year of Publication2018
AuthorsZong, C, Cheung-Lee, WLing, Elashal, HE, Raj, M, A Link, J
JournalChem Commun (Camb)
Date Published2018 Feb 01
KeywordsAcetylation, Acetyltransferases, Amino Acid Sequence, Bacterial Proteins, Peptides, Cyclic, Protein Processing, Post-Translational, Streptomyces

<p>We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.</p>

Alternate JournalChem Commun (Camb)
PubMed ID29350227
PubMed Central IDPMC5835390
Grant ListR01 GM107036 / GM / NIGMS NIH HHS / United States