| Title | Albusnodin: an acetylated lasso peptide from Streptomyces albus. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Zong, C, Cheung-Lee, WLing, Elashal, HE, Raj, M, A Link, J |
| Journal | Chem Commun (Camb) |
| Volume | 54 |
| Issue | 11 |
| Pagination | 1339-1342 |
| Date Published | 2018 Feb 01 |
| ISSN | 1364-548X |
| Keywords | Acetylation, Acetyltransferases, Amino Acid Sequence, Bacterial Proteins, Peptides, Cyclic, Protein Processing, Post-Translational, Streptomyces |
| Abstract | <p>We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.</p> |
| DOI | 10.1039/c7cc08620b |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 29350227 |
| PubMed Central ID | PMC5835390 |
| Grant List | R01 GM107036 / GM / NIGMS NIH HHS / United States |
