| Title | Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Liszczak, G, Diehl, KL, Dann, GP, Muir, TW |
| Journal | Nat Chem Biol |
| Date Published | 2018 Jul 16 |
| ISSN | 1552-4469 |
| Abstract | Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers. |
| DOI | 10.1038/s41589-018-0097-1 |
| Alternate Journal | Nat. Chem. Biol. |
| PubMed ID | 30013063 |
