|Title||Acetylation blocks DNA damage-induced chromatin ADP-ribosylation.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Liszczak, G, Diehl, KL, Dann, GP, Muir, TW|
|Journal||Nat Chem Biol|
|Date Published||2018 Jul 16|
Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.
|Alternate Journal||Nat. Chem. Biol.|