Acetylation blocks DNA damage-induced chromatin ADP-ribosylation.

TitleAcetylation blocks DNA damage-induced chromatin ADP-ribosylation.
Publication TypeJournal Article
Year of Publication2018
AuthorsLiszczak, G, Diehl, KL, Dann, GP, Muir, TW
JournalNat Chem Biol
Date Published2018 Jul 16
ISSN1552-4469
Abstract

Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.

DOI10.1038/s41589-018-0097-1
Alternate JournalNat. Chem. Biol.
PubMed ID30013063