| Title | Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Liszczak, G, Diehl, KL, Dann, GP, Muir, TW |
| Journal | Nat Chem Biol |
| Volume | 14 |
| Issue | 9 |
| Pagination | 837-840 |
| Date Published | 2018 09 |
| ISSN | 1552-4469 |
| Keywords | Acetylation, ADP-Ribosylation, Chromatin, Cloning, Molecular, DNA, DNA Damage, Histones, Humans, Tumor Cells, Cultured |
| Abstract | <p>Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.</p> |
| DOI | 10.1038/s41589-018-0097-1 |
| Alternate Journal | Nat Chem Biol |
| PubMed ID | 30013063 |
| PubMed Central ID | PMC6505472 |
| Grant List | F32 GM110880 / GM / NIGMS NIH HHS / United States P01 CA196539 / CA / NCI NIH HHS / United States R01 GM107047 / GM / NIGMS NIH HHS / United States R37 GM086868 / GM / NIGMS NIH HHS / United States F32 CA206418 / CA / NCI NIH HHS / United States |
